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Dyshomeostasis of Serum Oxidant/Antioxidant Status and Copper, Zinc, and Selenium Levels in Elderly Physically Disabled Persons: an AHAP-Based Study

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Abstract

The percentage of elderly persons is rapidly growing. Physical disability is one of the main age-related diseases which affect life quality. There are some studies that suggest the oxidative stress and trace elements are involved in physical disability in elderly persons, but the results are inconclusive. Therefore, the aim of this study was to investigate the status of aforementioned parameters in elderly physically disabled patients vs. healthy ones. According to the Katz questionnaire form, 44 subjects with physical disability and 66 age-gender-matched healthy subjects were selected from Amirkola Health and Aging Project (AHAP). The results indicated that patient group had lower serum Zn, Se, and total antioxidant levels than the control group (p < 0.001), whereas serum total oxidant level and Cu to Zn ratio (CZr) were higher in control group than in healthy one (p < 0.001). A positive correlation was found between Zn, Se, total antioxidant, and bone mineral density of femur (BMD.F) with activities of daily living (ADL) score (p < 0.01); meanwhile, a negative correlation between CZr and total oxidant with ADL score was observed (p < 0.01). Serum total oxidant level and CZr index had the highest area under the curve in receiver operating characteristic (ROC) analysis among the included parameters for discrimination of physically disabled patients than the normal ones. Decrease in serum Zn and Se levels, low BMD, and increase in CZr and oxidative stress were observed in physically disabled patients. It seems that CZr is more reliable parameter than the others to discriminate the physically disabled patients than the healthy persons.

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Acknowledgments

This study was supported by a grant number 2071 of Babol University of Medical Sciences, Babol, Iran. The authors thank Vice Chancellor for Research and Technology affairs for the approval of this study.

Conflict of Interest

There is no conflict of interest.

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Authors and Affiliations

  1. Department of Biochemistry and Biophysics, Babol University of Medical Sciences, Babol, Iran

    Simin Younesi, Abbas Mosapour & Sohrab Halalkhor

  2. Social Determinant of Health Research Center, Babol University of Medical Sciences, Ganjafrooz Ave, Babol, Iran

    Hadi Parsian, Seyed Reza Hosseini & Ali Bijani

  3. Department of Internal Medicine, Ayatollah Rouhani Hospital, Babol University of Medical Sciences, Babol, Iran

    Hajighorban Noreddini

Authors
  1. Simin Younesi
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  2. Hadi Parsian
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  3. Seyed Reza Hosseini
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  4. Hajighorban Noreddini
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  5. Abbas Mosapour
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  6. Ali Bijani
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  7. Sohrab Halalkhor
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Correspondence to Hadi Parsian.

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Younesi, S., Parsian, H., Hosseini, S.R. et al. Dyshomeostasis of Serum Oxidant/Antioxidant Status and Copper, Zinc, and Selenium Levels in Elderly Physically Disabled Persons: an AHAP-Based Study. Biol Trace Elem Res 166, 136–141 (2015). https://doi.org/10.1007/s12011-015-0261-3

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  • DOI: https://doi.org/10.1007/s12011-015-0261-3

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