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Possible Correlation of Selenoprotein W with Inflammation Factors in Chicken Skeletal Muscles

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Abstract

The aim of the present study was to investigate the possible correlation of selenoprotein W (SelW) with inflammatory injury induced by dietary selenium (Se) deficiency in chicken. One-day-old male chickens were fed either a commercial diet or a Se-deficient diet for 55 days. Then, the expression levels of SelW messenger RNA (mRNA) and inflammation-related genes (NF-κB, TNF-α, iNOS, COX-2, and PTGES) in chicken skeletal muscles (wing muscle, pectoral muscle, and thigh muscle) were determined at 15, 25, 35, 45, and 55 days old, respectively. In addition, the correlation between SelW mRNA expression and inflammation-related genes were assessed. The results showed that dietary Se deficiency reduced the mRNA expression of SelW in chicken wing, pectorals, and thigh muscles. In contrast, Se deficiency increased the mRNA expression levels of inflammation-related genes in chicken skeletal muscle tissues at different time points. The Pearson’s correlation coefficients showed that the mRNA expression levels of inflammation-related genes were significantly negative related to SelW (p < 0.05). These data showed that Se deficiency induced the inflammatory response in chicken skeletal muscle. As one important selenoprotein gene in skeletal muscles, SelW may play a role in the regulation of inflammation reaction in Se-deficiency myopathy.

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Acknowledgments

This study was supported by the Major Projects of International Cooperation and Exchanges NSFC (31320103920), the National Natural Science Foundation of China (31272626), the Doctoral Fund of the Ministry of Education of China (20122325110018), the Heilongjiang Postdoctoral Fund (LBH-Z13028), and the Heilongjiang Province Science Foundation for Youths (QC2014C015).

Conflict of Interest

The authors declare that there are no conflicts of interest.

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Authors and Affiliations

  1. College of Veterinary Medicine, Northeast Agricultural University, 59 Mucai Street, Xiangfang District, Harbin, 150030, People’s Republic of China

    Qiong Wu, Hai-Dong Yao, Si-ran Tan, Zi-Wei Zhang & Shiwen Xu

  2. College of Veterinary Medicine, China Agricultural University, Beijing, 100193, China

    Qiong Wu & Yao-hong Zhu

Authors
  1. Qiong Wu
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  2. Hai-Dong Yao
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  3. Si-ran Tan
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  4. Zi-Wei Zhang
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  5. Yao-hong Zhu
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  6. Shiwen Xu
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Corresponding authors

Correspondence to Yao-hong Zhu or Shiwen Xu.

Additional information

Qiong Wu and Hai-Dong Yao contributed equally to this work.

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Wu, Q., Yao, HD., Tan, Sr. et al. Possible Correlation of Selenoprotein W with Inflammation Factors in Chicken Skeletal Muscles. Biol Trace Elem Res 161, 167–172 (2014). https://doi.org/10.1007/s12011-014-0092-7

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  • DOI: https://doi.org/10.1007/s12011-014-0092-7

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