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Effects of Zinc Supplementation on the Element Distribution in Kidney Tissue of Diabetic Rats Subjected to Acute Swimming

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Abstract

In this study, we report the effect of zinc supplementation on the distribution of elements in kidney tissue of diabetic rats subjected to acute swimming exercise. Diabetes was induced by two subcutaneous injections of 40 mg/kg of streptozotocin within a 24-h period. Zinc was given intraperitoneally at a dose of 6 mg/kg per day for a period of 4 weeks. The rats (n = 80) were equally divided into eight study groups: controls, zinc-supplemented, swimming, diabetic, zinc-supplemented diabetic, zinc-supplemented swimming, diabetic swimming, and zinc-supplemented diabetic swimming. The levels of lead, cobalt, molybdenum, chromium, boron, magnesium, iron, copper, calcium, zinc, and selenium were determined in the kidney tissue samples by ICP-AES. Higher molybdenum, calcium, zinc, and selenium values were found in both swimming and nonswimming diabetic rats. Significantly higher iron values were found in swimming, diabetic, diabetic swimming, and zinc-supplemented diabetic swimming rats (p < 0.001). Diabetic, zinc-supplemented diabetic, diabetic swimming, and zinc-supplemented diabetic swimming rats had the highest copper values. These results show that zinc supplementation normalized the higher levels of molybdenum, calcium, selenium, and iron levels seen in diabetic rats, indicating that zinc may have a regulatory effect on element metabolism in kidney tissue.

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Authors and Affiliations

  1. Department of Biochemistry, Selcuklu School of Medicine, Selçuk University, Konya, Turkey

    Abdullah Sivrikaya

  2. School of Physical Education and Sports, Selçuk University, Konya, Turkey

    Mursel Bicer

  3. Hasan Dogan High School of Physical Education and Sports, Karabuk University, Karabuk, Turkey

    Mustafa Akil

  4. Department of Physiology, Selcuklu Medical School, Selcuk University, Campus, 42031, Selçuklu, Konya, Turkey

    Abdulkerim Kasim Baltaci & Rasim Mogulkoc

Authors
  1. Abdullah Sivrikaya
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  2. Mursel Bicer
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  3. Mustafa Akil
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  4. Abdulkerim Kasim Baltaci
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  5. Rasim Mogulkoc
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Correspondence to Abdulkerim Kasim Baltaci.

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Sivrikaya, A., Bicer, M., Akil, M. et al. Effects of Zinc Supplementation on the Element Distribution in Kidney Tissue of Diabetic Rats Subjected to Acute Swimming. Biol Trace Elem Res 147, 195–199 (2012). https://doi.org/10.1007/s12011-011-9284-6

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  • DOI: https://doi.org/10.1007/s12011-011-9284-6

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