Skip to main content

Advertisement

Log in

Mercury Concentration in the Breast Milk of Iranian Women

  • Published:
Biological Trace Element Research Aims and scope Submit manuscript

Abstract

Human milk is usually the only source of food for infants during the first 4 to 5 months of their life. In this research, 80 human milk samples were collected from mothers in Tehran, Noushahr and the countryside of Tabriz, Iran, who were not occupationally exposed to mercury. The mean concentration of mercury in breast milk obtained from mothers in the countryside of Tabriz, Noushahr and Tehran was 0.86, 0.15 and 0.12 μg/L, respectively. There was a significant difference in mercury concentration in human breast milk between that from the countryside of Tabriz with that from Tehran and Noushahr. Only 3.7% of infant samples (three infants) had mercury concentration higher than normal versus the WHO recommended limit (0.5 μg g−1). The fish consumption of these mothers in Tehran and Noushahr was a factor that significantly affected the mercury concentration in their breast milk. Also, their age affected the mercury levels in breast milk (p = 0.04).

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Fig. 1

Similar content being viewed by others

References

  1. Clarkson TW, Magos L, Myers GJ (2003) The toxicology of mercury—current exposures and clinical manifestations. N Engl J Med 18:1731–1737

    Article  Google Scholar 

  2. Davidson PW, Myers GJ, Weiss B (2004) Mercury exposure and child development outcomes. Pediatrics 113:1023–1029

    PubMed  Google Scholar 

  3. Clarkson TW, Magos L (2006) The toxicology of mercury and its chemical compounds. Crit Rev Toxicol 36:609–662

    Article  PubMed  CAS  Google Scholar 

  4. Jaffe D, Prestbo E, Swartzendruber P, Weiss-Penzias P, Kato S, Takami A, Hatakeyama S, Kajii Y (2005) Export of atmospheric mercury from Asia. Atmos Environ 39:3029–3038

    Article  CAS  Google Scholar 

  5. Wong CSC, Duzgoren-Aydin NS, Aydin A, Wong MH (2007) Sources and trends of environmental mercury emissions in Asia. Sci Total Environ 368:649–662

    Google Scholar 

  6. United States Environmental Protection Agency (1997) Health effects of mercury and mercury compounds. Study report EPA-452/R-97-007. US EPA, vol. V

  7. Risher J, DeWoskin R (2004) Toxicological profile for mercury. US Department of Health and Human Services, Public Health Service. Agency for Toxic Substances and Disease Registry, Atlanta

    Google Scholar 

  8. WHO (1996) Lead, cadmium and mercury. In: Trace elements in human nutrition and health. WHO, Geneva

    Google Scholar 

  9. Oskarsson A, Palminger HI, Sundberg J (1995) Exposure to toxic elements via breast milk. Analyst 120:765–770

    Article  PubMed  CAS  Google Scholar 

  10. Foo SC, Tan TC (1998) Elements in the hair of South-east Asian islanders. Sci Total Environ 209:185–192

    Article  PubMed  CAS  Google Scholar 

  11. Bloom NS (1992) On the chemical form of mercury in edible fish and marine invertebrate tissue. Can J Fish Aquat Sci 49:1010–1017

    Article  CAS  Google Scholar 

  12. Kim JP (1995) Methyl mercury in rainbow trout (Oncorhynchus mykiss) from lakes Okareka, Rotomahana, Rotorua and Tarawera, North Island, New Zealand. Sci Total Environ 164:209–219

    Article  CAS  Google Scholar 

  13. USEPA (2001) Mercury update: impact on fish advisories. EPA-823-F-01-011. Office of Water, Washington, DC

    Google Scholar 

  14. Grandjean P, Weihe P, White RF, Debes F, Araki S, Yokoyama K, Murata K, Sørensen N, Dahl R, Jørgensen PJ (1997) Cognitive deficit in 7-year-old children with prenatal exposure to methylmercury. Neurotox Teratol 19:417–428

    Article  CAS  Google Scholar 

  15. Myers GJ, Davidson PW (2000) Does methylmercury have a role in causing developmental disabilities in children? Environ Health Perspect 108:413–420

    PubMed  Google Scholar 

  16. Myers GJ, Davidson PW, Cox C, Shamlaye CF, Palumbo D, Cernichiari C, Cernichiari E, Sloane-Reeves J, Wilding GE, Kost J, Huang LS, Clarkson TW (2003) Prenatal methylmercury exposure from ocean fish consumption in the Seychelles Child Development Study. Lancet 361:1686–1692

    Article  PubMed  CAS  Google Scholar 

  17. van Wijngaarden E, Beck C, Shamlaye CF, Cernichiari E, Davidson PW, Myers GJ, Clarkso TW (2006) Benchmark concentrations for methyl mercury obtained from the 9-year follow-up of the Seychelles Child Development Study. Neurotoxicology 27:702–709

    Article  PubMed  Google Scholar 

  18. Norouzi E, Bahramifar N, Ghasempouri SM (2011) Effect of teeth amalgam on mercury levels in the colostrums human milk in Lenjan. Environ Monit Assess. doi:10.1007/s10661-011-1974-1

  19. Al-Majed NB, Preston MR (2000) Factors influencing the total mercury and methylmercury in the hair of the fishermen of Kuwait. J Environ Popul 109:239–250

    CAS  Google Scholar 

  20. Roos-Barraclough F, Givelet N, Martinez-Cortizas A, Goodsite ME, Biester H, Shotyk W (2002) An analytical protocol for the determination of total mercury concentrations in solid peat samples. Sci Tot Environ 292:129–139

    Article  CAS  Google Scholar 

  21. Szkoda J, Zmudzki J, Grzebalska A (2006) Determination of total mercury in biological material by atomic absorption spectrometry method. Bull Vet Inst Pulawy 50:363–366

    Google Scholar 

  22. FAO/WHO (1978) Evaluation of certain food additives and contaminants: twenty-second report of the Joint FAO/WHO Expert Committee on Food Additives. WHO Technical Report Series, vol 631. WHO, Geneva

    Google Scholar 

  23. FAO/WHO (1993) Evaluation of certain food additives and contaminants: forty-first report of the Joint FAO/WHO Expert Committee on Food Additives). WHO Technical Report Series, vol 837. WHO, Geneva

    Google Scholar 

  24. Chien LC, Han BC, Hsuu CS, Jiang CB, You HJ, Shieh MJ, Yeh CY (2006) Analysis of the health risk of exposure to breast milk mercury in infants in Taiwan. Chemospher 64:79–85

    Article  CAS  Google Scholar 

  25. Bose-o Reilly S, Lettmeier B, Roider G, Siebert U, Drasch G (2008) Mercury in breast milk—a health hazard for infants in gold mining areas? Int. J Hyg Environ Health 211:615–623

    Article  CAS  Google Scholar 

  26. Barbosa AC, Dorea JG (1998) Indices of mercury contamination during breast feeding in the Amazon Basin. Environ Toxicolog Pharmacol 6:71–79

    Article  CAS  Google Scholar 

  27. Nunes-Junior GP, Sote’rio NMF (2000) Possible mercury intoxication of new borns via breast milk. Front Fetal Health 2:18–20

    Google Scholar 

  28. Yalcin SS, Yurdakök K, Yalçın S, Engür-Karasimav D, Coşkun T (2010) Maternal and environmental determinants of breast-milk mercury concentrations. Turk J Pediatr 52:1–9

    PubMed  Google Scholar 

  29. Oskarsson A, Schutz A, Skerfving S, Palminger Halle’n I, Ohlin B, Lagerkvist BJ (1996) Total and inorganic mercury in breast milk and blood in relation to fish consumption and amalgam fillings in lactating women. Arch Environ Health 513:234–241

    Article  Google Scholar 

  30. Vimy MJ, Hooper DE, King WW, Lorscheider FL (1997) Mercury from maternal “silver” tooth fillings in sheep and human breast milk. A source of neonatal exposure. Biol Trace Elem Res 56:143–152

    Article  PubMed  CAS  Google Scholar 

  31. Plockinger B, Dadak C, Meisinger V (1993) Lead, mercury and cadmium in newborn infants and their mothers (in German). Z Geburtshilfe Perinatol 197:104–107

    PubMed  CAS  Google Scholar 

  32. Barej R, Kwaśnicki R, Chojnacka K, Bolanowski J, Dobrzański Z, Pokorny P (2009) Mercury content in rural and industrial regions in Lower Silesia. Pol J Environ Stud 18:547–552

    CAS  Google Scholar 

  33. Naghdi F (2010) Effects of biologic sludge Tabriz Petrochemical on accumulation heavy metal in soil. Fifth Conference CELCO, Tehran

    Google Scholar 

  34. Asadi Y (2009) Measurement of heavy metals mercury, lead and cadmium in drinking water. Tabriz City Plan Research of Nutritional Research Center

    Google Scholar 

  35. Ranjbar A, Shakeri M (2009) Application of Geographic Information System at Management of Air Pollution of Tabriz City. Fourth Conference CELCO, Tehran

    Google Scholar 

  36. SobhanVardi J, Ziaee AR (2009) Investigate effects leather factory on water source Mayan desert. Fourth Conference CELCO, Tehran

    Google Scholar 

  37. Frkovic A, Kras M, Alebiæ-Juretiæ A (1997) Lead and cadmium content in human milk from the northern Adriatic area of Croatia. Bull Environ Contam Toxicol 58:16–21

    Article  PubMed  CAS  Google Scholar 

  38. Guidi B, Ronchi S, Ori E et al (1992) Lead concentrations in breast milk of women living in urban areas compared with women living in rural areas. Pediatr Med Chir 146:611–616

    Google Scholar 

  39. Dorea JG (2004) Mercury and lead during breast-feeding. Br J Nutr 92:21–40

    Article  PubMed  CAS  Google Scholar 

  40. Kacmar P, Legath J, Neuschl J (1992) Levels of mercury in the organs and tissues of sheep after administration of very low doses. Vet Med (Praha) 37:231–235 [article in Slovak]

    CAS  Google Scholar 

  41. Sharma R, Pervez S (2005) Toxic metals status in human blood and breast milk samples in an integrated steel plant environment in Central India. Environ Geochem Health 27:39–45

    Article  PubMed  CAS  Google Scholar 

  42. Saleh IAL, Shinwari N, Mashhour A (2003) Heavy metal concentrations in the breast milk of Saudi women. Biol Trace Elem Res 96(1–3):21–37

    Article  Google Scholar 

  43. Juszkiewicz T, Szprengier T, Radomanski T (1975) Mercury content of human milk. Pol Tyg Lek 30:365–366

    PubMed  CAS  Google Scholar 

  44. Ursinyova M, Masanova V (2005) Cadmium, lead and mercury in human milk from Slovakia. Food Addit Contam 22:579–589

    Article  PubMed  CAS  Google Scholar 

  45. Gundacker C, Pietschnig B, Wittmann K, Lischka A, Salzer H, Hohenauer L, Schuster E (2002) Lead and mercury in breast milk. Pediatrics 110(5):873–878

    Article  PubMed  Google Scholar 

  46. Agah H, Leermakers M, Elskens M, Fatemi M, Baeyens W (2007) Total mercury and methyl mercury concentrations in fish from the Persian Gulf and the Caspian Sea. Water Air Soil Pollut 181:95–105

    Article  CAS  Google Scholar 

  47. McDowell MA, Dillon CF, Osterloh J, Bolger PM, Pellizzari E, Fernando R (2004) Hair mercury levels in US children and women of childbearing age: reference range data from NHANES 1999–2000. Environ Health Perspect 112:1165–1171

    Article  PubMed  CAS  Google Scholar 

  48. Batista J, Schuhmacher M, Domingo JL, Corbella H (1996) Mercury in hair for a child population from Tarragona province, Spain. Sci Tot Environ 193:143–148

    Article  CAS  Google Scholar 

  49. Holsbeek L, Das HK, Joiris CR (1996) Mercury in human hair and relation to fish consumption in Bangladesh. J Sci Total Environ 186:181–188

    Article  CAS  Google Scholar 

  50. Harada M, Nakanishi J, Konuma S, Ohno K, Kimura T, Yamaguchi H, Tsuruta K, Kizaki T, Ookawara T, Ohno H (1998) The present mercury contents of scalp hair and clinical symptoms in inhabitants of the Minamata area. J Environ Res 77:160–164

    Article  CAS  Google Scholar 

  51. Al-Majed NB, Preston MR (2000) Factors influencing the total mercury and methylmercury in the hair of the fishermen of Kuwait. J Environ Popull 109:239–250

    Article  CAS  Google Scholar 

  52. Olivero J, Johnson B, Arguello E (2002) Human exposure to mercury in San Jorge river basin, Colombia, South America. J Sci Total Environ 289:41–47

    Article  CAS  Google Scholar 

  53. Santos ECO, Camara VM, Jesus IM, Brabo ES, Loureiro ECB, Mascarenhas AFS, Fayal KF, Sa Filho GC, Sagica FES, Lima MO, Higuchi H, Silveira IM (2002) A contribution to the establishment of reference values for total mercury levels in hair and fish in Amazonia. J Environ Res 90:6–11

    Article  CAS  Google Scholar 

  54. Yasutake A, Matsumoto M, Yamaguchi M, Hachiya N (2003) Current hair mercury levels in Japanese: survey in five districts. Tohoku J Experi Med 19:161–169

    Article  Google Scholar 

  55. Grandjean P, Weihe P, Needham LL, Burse VW, Patterson JDG, Sampson EJ, Jorgensen PJ, Vahter M (1995) Relation of a seafood diet to mercury, selenium, arsenic, and polychlorinated biphenyl and other organochlorine concentrations in human milk. Environ Res 71:29–38

    Article  PubMed  CAS  Google Scholar 

  56. Foroghi R, Esmaili-sari A, Ghasempouri SM (2007) The comparison of correlation between aggregation of mercury in various organs with length and weight of Rutilus frisii kutum in south Caspian Sea coast. Sci J Iran Fish 15:97–104

    Google Scholar 

  57. Taheri-azad L, Ghasempouri SM, Rezayee-tawabae K (2007) The initial report of mercury pollution in case of environmental toxic element in liver of Sander Luciperca in Caspian Sea. Paper presented at the First Specialty Conference of Environment Engineering, Tehran

    Google Scholar 

  58. Yazdani-nasab L, Esmaili-sari A, Abtahi B, Ghasempouri SM (2007) The survey of density and bioaccumulation of mercury in various tissues of Liza aurata in south of Caspian sea. Paper presented at the First Specialty Conference of Environment Engineering, Tehran

    Google Scholar 

  59. Pronczuk J, Akre J, Moy G, Vallenas C (2002) Global perspectives in breast milk contamination: infectious and toxic hazards. Environ Health Perspect 110A:349–5

    Article  Google Scholar 

  60. Oddy WH (2001) Breast-feeding protects against illness and infection in infants and children. A review of the evidence. Breastfeed Rev 9(2):11–18

    PubMed  CAS  Google Scholar 

  61. Drasch G, Aigner S, Roider G, Staiger F, Lipowsky G (1998) Mercury in human colostrum and early breast milk. Its dependence on dental amalgam and other factors. J Trace Elem Med Biol 12:23–27

    Article  PubMed  CAS  Google Scholar 

  62. Langworth S, Elinder CG, Gothe CJ, Vesterberg O (1991) Biological monitoring of environmental and occupational exposure to mercury. Int Arch Occup Environ Health 633:161–167

    Article  Google Scholar 

  63. Klemann D, Weinhold J, Strubelt O, Pentz R, Jungblut JR, Klink F (1990) Effects of amalgam fillings on the mercury concentrations in amniotic fluid and breast milk. Dtschz Ahna¨rztl Z 453:142–145

    Google Scholar 

  64. Jones DW (1999) Exposure or absorption and the crucial question of limits for mercury. J Can Dent Assoc 651:42–46

    Google Scholar 

  65. Drexler H, Schaller KH (1998) The mercury concentration in breast milk resulting from amalgam fillings and dietary habits. Environ Res 772:124–129

    Article  Google Scholar 

  66. WHO/FAO (1989) Toxicological evaluation of certain food additives and contaminants. WHO Food Additives Series: 24. Cambridge University Press, pp 295–28

  67. Paccagnella B, Riolfatti M (1989) Total mercury levels in human milk from Italian mothers having not been particularly exposed to methyl-mercury. Ann Ig 1:661–671

    PubMed  CAS  Google Scholar 

  68. Barbosa AC, Silva SRL, Dorea JG (1998) Concentration of mercury in hair of indigenous mothers and infants from the Amazon Basin. Arch Environ Contam Toxicol 34:100–105

    Article  PubMed  CAS  Google Scholar 

Download references

Acknowledgements

The authors thank Dr. Alipor, Mrs. Safora Dahmardeh Behrooz and Faride Naghdi and Zahra Shokri for providing the lactating women's list of names and collection in Noushar, Tehran and the countryside of Tabriz Central Health.

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Reza Dahmardeh Behrooz.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Dahmardeh Behrooz, R., Esmaili-Sari, A., Peer, F.E. et al. Mercury Concentration in the Breast Milk of Iranian Women. Biol Trace Elem Res 147, 36–43 (2012). https://doi.org/10.1007/s12011-011-9283-7

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s12011-011-9283-7

Keywords

Navigation