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RETRACTED ARTICLE: Effects of Cadmium Chloride and Sodium Selenite Alone or in Combination on the Liver of Male Sprague–Dawley Rats Assessed by Different Assays

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Abstract

This study assessed the impact of either cadmium chloride (Cd) or sodium selenite (Se) alone or in combination on male Sprague–Dawley rats. For this purpose, body and liver weights, comet and TUNEL assays, histological analysis and levels of lipid peroxidation and antioxidants in liver were determined in four groups of male Sprague–Dawley rats. The rats were given subcutaneous doses of 1 mg/kg body weight (BW) of either normal saline (control = Ct) or Cd or Se or Cd plus Se (Cd + Se) on alternate days for 4 weeks. The Cd group showed increased DNA damage, apoptosis and hepatic levels of lipid peroxidation and altered histology. Conversely, the antioxidant levels in this group were decreased as compared with the control group. The Se group also showed DNA damage, apoptosis and altered histology and reduced catalase activity, but it was less severe than the Cd group. In the Cd + Se group, ameliorating effects of Se on Cd-induced changes were observed. While the Se was able to curtail the toxic effect of Cd, the Cd or Se alone were genotoxic and cytotoxic for rats receiving a high pharmacological but non-fatal dose of 1 mg/kg BW.

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Acknowledgements

Thanks to the Islamic Development Bank Jeddah, Saudi Arabia for funding this post-doctoral research at Newcastle University and Professor Dr. Samina Jalali, Dr. Sarwat Jahan, Dr. Robina Shaheen, Riffat Gillani, Noshaba Memon and Aysha Ambreen for their help and support during the rat trials at Quaid-i-Azam University Islamabad, Pakistan.

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Authors and Affiliations

  1. Department of Zoology, GC University Faisalabad, Faisalabad, Pakistan

    Farhat Jabeen

  2. School of Agriculture Food and Rural Development, Newcastle University, Newcastle upon Tyne, UK

    Farhat Jabeen & Abdul Shakoor Chaudhry

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  1. Farhat Jabeen
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  2. Abdul Shakoor Chaudhry
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Correspondence to Farhat Jabeen.

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This article has been retracted. Please see the retraction notice for more detail: https://doi.org/10.1007/s12011-024-04125-4

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Jabeen, F., Chaudhry, A.S. RETRACTED ARTICLE: Effects of Cadmium Chloride and Sodium Selenite Alone or in Combination on the Liver of Male Sprague–Dawley Rats Assessed by Different Assays. Biol Trace Elem Res 143, 1077–1090 (2011). https://doi.org/10.1007/s12011-010-8946-0

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  • DOI: https://doi.org/10.1007/s12011-010-8946-0

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