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Status of Copper and Magnesium Levels in Diabetic Nephropathy Cases: a Case-Control Study from South India

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Abstract

Diabetic nephropathy is a complication of diabetes mellitus. This present study investigates the status of copper and magnesium in diabetic nephropathy cases to establish a possible relation. Forty patients of diabetic nephropathy participated in the study as cases. Forty age- and sex-matched healthy individuals served as controls. Blood samples were collected from both cases and controls for determination of FBS, PPBS, HbA1c, microalbumin, copper, and magnesium levels. The mean concentrations of FBS, PPBS, HbA1c, and microalbumin of cases were significantly higher than that of controls. The mean magnesium levels of cases (1.60 ± 0.32 meq/L) were significantly lower than controls 2.14 ± 0.16 meq/L (p < 0.05). But the mean copper levels of cases, 165.42 ± 5.71 μg/dl, shows no significant difference with controls, 166.6 ± 5.48 μg/dl, (p > 0.05).The findings in the present study suggest that hypomagnesemia may be linked with development of diabetic nephropathy.

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Acknowledgements

We thank Mrs. Saritha, Lecturer in Statistics, Department of Community Medicine, NRI Medical College, Chinakakani, for her assistance during statistical analysis.

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Authors and Affiliations

  1. Department of Biochemistry, NRI Medical College and General Hospital, Chinakakani, 522 503, Guntur district, Andhra Pradesh, India

    S. Prabodh, N. V. S. Chowdary, V. Desai & R. Shekhar

  2. Department of Human Genetics, Andhra University, Visakhapatnam, 530 003, Andhra Pradesh, India

    D. S. R. S. Prakash & G. Sudhakar

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  1. S. Prabodh
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  2. D. S. R. S. Prakash
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  3. G. Sudhakar
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  4. N. V. S. Chowdary
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  5. V. Desai
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  6. R. Shekhar
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Correspondence to D. S. R. S. Prakash.

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Prabodh, S., Prakash, D.S.R.S., Sudhakar, G. et al. Status of Copper and Magnesium Levels in Diabetic Nephropathy Cases: a Case-Control Study from South India. Biol Trace Elem Res 142, 29–35 (2011). https://doi.org/10.1007/s12011-010-8750-x

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