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Association of serum uric acid with nephropathy in Iranian type 2 diabetic patients

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Abstract

Background

Diabetic nephropathy (DN) is the major cause of end-stage renal disease. Recent studies suggest that it is probable that uric acid is involved in the pathogenesis of diabetic nephropathy. This study aim was to investigate the association between serum uric acid and kidney function in Iranian patients with type 2 diabetes mellitus.

Methods

In this case-control study, a total of 201 diabetic patients with or without impaired kidney function (glomerular filtration rate/GFR < 60 and GFR ≥ 60) were selected. In both groups, serum fasting glucose (FBS), HbA1c, urea, creatinine, uric acid and lipid profile, urine albumin and GFR were measured and results were compared between the two groups. The results also categorized into three groups based on uric acid tertiles.

Results

Serum levels of uric acid, urea and creatinine as well as urine albumin/creatinine ratio (ACR) were significantly different between the two groups. GFR, creatinine and also urea were significantly different between uric acid tertiles (p < 0.05).

Conclusions

Serum uric acid is associated with decreased GFR as well as albuminuria and can be used as an indicator of DN.

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Abbreviations

ACR:

Albumin to Creatinine Ratio

ANOVA:

One-way analysis of variance

CKD:

Chronic Kidney Diseases

DN:

Diabetic Nephropathy

ESRD:

End Stage Renal Diseases

FBS:

Fasting Blood Sugar

GFR:

Glomerular Filtration Rate

MDRD:

Modification of Diet in Renal Disease

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Acknowledgements

The authors wish to thank staffs at Diabetes Research Center for their assistance in the study.

Funding

This research did not receive any specific grant from funding agencies in the public, commercial, or not-for-profit sectors.

Author information

Authors and Affiliations

  1. Diabetes Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, 5th floor, Diabetes Clinic, cross Heyat Ave, Shahrivar Ave., North Kargar St, Tehran, 1411715851, Iran

    Farideh Razi & Fatemeh Bandarian

  2. Endocrinology and Metabolism Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran

    Ensieh Nasli-Esfahani

Authors
  1. Farideh Razi
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  2. Ensieh Nasli-Esfahani
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  3. Fatemeh Bandarian
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Contributions

FR: study design and concept, performing assay and approving final manuscript.

FB: Data collection, statistical analysis and approving final manuscript.

EN: data interpretation, writing first manuscript draft and approving final manuscript.

Corresponding author

Correspondence to Fatemeh Bandarian.

Ethics declarations

Ethics approval and consent to participate

The study protocol was approved by the Ethics Committee of the Endocrinology and Metabolism Research Institute (EMRI) affiliated to Tehran University of Medical Sciences and all participants signed written informed consent.

Competing interest

The authors have no conflict of interest regarding this study to report.

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Razi, F., Nasli-Esfahani, E. & Bandarian, F. Association of serum uric acid with nephropathy in Iranian type 2 diabetic patients. J Diabetes Metab Disord 17, 71–75 (2018). https://doi.org/10.1007/s40200-018-0340-z

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  • DOI: https://doi.org/10.1007/s40200-018-0340-z

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