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Cadmium Reduces Contractile Responses of Rat Duodenum, In Vitro

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Abstract

The present study focuses on the effects of cadmium in drinking water on rat duodenum contractility, in vitro. Two experimental groups (n = 10 each) were administered with 15 ppm cadmium chloride in their drinking water for 1 and 2 months, respectively. Two separate groups (n = 10 each) were maintained in similar conditions but received no cadmium and acted as controls. After the experimental period, the duodenal segment responses were measured by means of an isotonic transducer. The average peak amplitude of acetylcholine-induced contractions was significantly decreased in both cadmium-treated groups. Incubation of duodena from the cadmium-free controls with atropine or in a calcium-free medium resulted in reduced contractility that was undistinguishable from that of the cadmium-treated rats. Cadmium reduces the contractile response apparently by directly or indirectly decreasing cellular calcium influx.

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Acknowledgment

We thank the Ankara University Management of Scientific Research Projects for their support of this project, number 2003/0809123.

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Authors and Affiliations

  1. Department of Physiology, Faculty of Medicine, Ankara University, Morphology Campus, 06100, Sihhiye, Ankara, Turkey

    Emine Koç

  2. Department of Pathophysiology, Faculty of Medicine, Ankara University, Morphology Campus, 06100, Sihhiye, Ankara, Turkey

    Mehtap Koçak & Ethem Akçil

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  1. Emine Koç
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Correspondence to Mehtap Koçak.

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Koç, E., Koçak, M. & Akçil, E. Cadmium Reduces Contractile Responses of Rat Duodenum, In Vitro. Biol Trace Elem Res 123, 154–160 (2008). https://doi.org/10.1007/s12011-008-8103-1

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  • DOI: https://doi.org/10.1007/s12011-008-8103-1

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