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Improving Nonenzymatic Biosensing Performance of Electrospun Carbon Nanofibers decorated with Ni/Co Particles via Oxidation

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Abstract

Nonenzymatic biosensors do not require enzyme immobilization nor face degradation problem. Hence, nonenzymatic biosensors have recently attracted growing attention due to the stability and reproducibility. Here, a comparative study was conducted to quantitatively evaluate the glucose sensing of pure/oxidized Ni, Co, and their bimetal nanostructures grown on electrospun carbon nanofibers (ECNFs) to provide a low-cost free-standing electrode. The prepared nanostructures exhibited sensitivity (from 66.28 to 610.6 μA mM−1 cm−2), linear range of 2–10 mM, limit of detection in the range of 1 mM, and the response time (< 5 s), besides outstanding selectivity and applicability for glucose detection in the human serum. Moreover, the oxidizable interfering species, such as ascorbic acid (AA), uric acid (UA), and dopamine (DA), did not cause interference. Co–C and Ni-C phase diagrams, solid-state diffusion phenomena, and rearrangement of dissolved C atoms after migration from metal particles were discussed. This study undoubtedly provides new prospects on the nonenzymatic biosensing performance of mono-metal, bimetal, and oxide compounds of Ni and Co elements, which could be quite helpful for the fabrication of biomolecules detecting devices.

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Authors and Affiliations

  1. Department of Polymer Engineering and Color Technology, Amirkabir University of Technology, P.O. Box, 15875-4413, Tehran, Iran

    Ali Mohammadpour-Haratbar & Farhad Sharif

  2. New Technologies Research Center (NTRC), Amirkabir University of Technology, 15875- 4413, Tehran, Iran

    Saeedeh Mazinani & Ali Mohammad Bazargan

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  1. Ali Mohammadpour-Haratbar
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  2. Saeedeh Mazinani
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  4. Ali Mohammad Bazargan
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Correspondence to Saeedeh Mazinani.

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Research Highlights

• Introducing well-stablished method for synthesis nanocomposites of electrospun carbon nanofibers decorated with pure/oxidized metal nanoparticles.

• Designing free-stand nonenzymatic electrodes of electrospun carbon nanofibers with no need to binders and glassy carbon electrode.

• Obtaining biosensors of high sensitivity and wide linear range towards the oxidation of glucose.

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Mohammadpour-Haratbar, A., Mazinani, S., Sharif, F. et al. Improving Nonenzymatic Biosensing Performance of Electrospun Carbon Nanofibers decorated with Ni/Co Particles via Oxidation. Appl Biochem Biotechnol 194, 2542–2564 (2022). https://doi.org/10.1007/s12010-022-03833-8

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