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Antioxidative and DNA Protective Effects of Bacillomycin D-Like Lipopeptides Produced by B38 Strain

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Abstract

In the present study, we evaluated the antioxidant and the scavenging ability of C14, C15 and C16 bacillomycin D-like lipopeptides produced by B38 strain. They all displayed strong reducing power activity, hydroxyl and superoxide anion radicals scavenging activities and inhibition of lipid peroxidation. In addition, they were found to protect plasmid DNA damage from hydroxyl radical oxidation. Data suggested that their antioxidant potency can be attributed to the hydrophobic and aromatic side-chain groups of their amino acids as well as to the aliphatic chain of their beta amino fatty acids. Note that the hydrocarbon chain length did not interfere with the antioxidant power. Overall, such bacillomycin D lipopeptides which exhibit antioxidant and radical scavenging activities may be useful for cosmetic, therapeutic or pharmaceutical purposes in order to delay or prevent oxidative deterioration of manufactured products.

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Acknowledgements

This work was financially supported by grants from the Tunisian Ministry of Higher Education and Scientific Research. We would like to thank Prof. Ezzedine Aouani for critically reading the manuscript.

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Authors and Affiliations

  1. Laboratoire des Substances Bioactives, Centre de Biotechnologie de Borj-Cedria, BP-901, 2050, Hammam-lif cedex, Tunisia

    Olfa Tabbene, Dorra Gharbi, Imen Ben Slimene, Salem Elkahoui & Ferid Limam

  2. Laboratoire de Phytobactériologie, UR Agrobiotechnologie, Institut National de Recherches Agronomiques, Marrakech, Morocco

    Mohamed Najib Alfeddy

  3. UMR 6270 CNRS, Faculté des Sciences, Université de Rouen, 76821, Plate-Forme de Protéomique, Mont Saint Aignan Cedex, France

    Pascal Cosette & Thierry Jouenne

  4. Dipartimento di Scienze Biochimiche, Università La Sapienza, Piazzale Aldo Moro, 5-00185, Roma, Italy

    Maria Luisa Mangoni

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  1. Olfa Tabbene
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  2. Dorra Gharbi
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  3. Imen Ben Slimene
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  4. Salem Elkahoui
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  5. Mohamed Najib Alfeddy
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  6. Pascal Cosette
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  7. Maria Luisa Mangoni
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  8. Thierry Jouenne
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  9. Ferid Limam
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Correspondence to Ferid Limam.

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Tabbene, O., Gharbi, D., Slimene, I.B. et al. Antioxidative and DNA Protective Effects of Bacillomycin D-Like Lipopeptides Produced by B38 Strain. Appl Biochem Biotechnol 168, 2245–2256 (2012). https://doi.org/10.1007/s12010-012-9933-z

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  • DOI: https://doi.org/10.1007/s12010-012-9933-z

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