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Topoisomerase Inhibition, Nucleolytic and Electrolytic Contribution on DNA Binding Activity Exerted by Biological Active Analogue of Coordination Compounds

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Abstract

The neutral mononuclear copper complexes with the quinolone antibacterial drug ciprofloxacin and bipyridine derivatives have been synthesized and characterized. Complexes were screened for their antibacterial activity against three Gram(−) and two Gram(+) bacteria, and study suggests inhibition of gyrase activity by metal complexes as the possible mechanism. The nucleolytic activity of adducts was carried out on double stranded pUC19 DNA using gel electrophoresis in the presence of radical scavenging agents that suggest hydrolytic cleavage mechanism for plasmid DNA.

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Acknowledgments

We thank the authority Head, Department of Chemistry, Sardar Patel University, Vallabh Vidyanagar, Gujarat, India for providing the laboratory facilities. The authors would also like to acknowledge U.G.C. for providing financial assistance through UGC grant 32-226/2006(SR).

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  1. Department of Chemistry, Sardar Patel University, Vallabh Vidyanagar, 388 120, Gujarat, India

    Mohan N. Patel, Bhupesh S. Bhatt & Promise A. Dosi

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  1. Mohan N. Patel
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  2. Bhupesh S. Bhatt
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  3. Promise A. Dosi
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Correspondence to Mohan N. Patel.

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Patel, M.N., Bhatt, B.S. & Dosi, P.A. Topoisomerase Inhibition, Nucleolytic and Electrolytic Contribution on DNA Binding Activity Exerted by Biological Active Analogue of Coordination Compounds. Appl Biochem Biotechnol 166, 1949–1968 (2012). https://doi.org/10.1007/s12010-012-9623-x

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