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Single-step conversion of cephalosporin-C to 7-Aminocephalosporanic acid by free and immobilized cells of Pseudomonas diminuta

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Abstract

7-Aminocephalosporanic acid (7-ACA), the starting material for the production of a number of clinically used semisynthetic cephalosporins, is produced by deacylation of cephalosporin-C. The production of 7-ACA was studied in various modes, at the optimal conditions using free and immobilized whole cells of Pseudomonas diminuta.

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Authors and Affiliations

  1. Birla Institute of Scientific Research, Statue Circle, 302001, Jaipur, Rajasthan

    V. K. N. Igam & P. Gohsh

  2. School of Biochemical Engineering, Institute of Technology, Banaras Hindu University, 221005, Varanasi, India

    S. Knudu

Authors
  1. V. K. N. Igam
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  2. S. Knudu
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  3. P. Gohsh
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Correspondence to V. K. N. Igam.

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Igam, V.K.N., Knudu, S. & Gohsh, P. Single-step conversion of cephalosporin-C to 7-Aminocephalosporanic acid by free and immobilized cells of Pseudomonas diminuta . Appl Biochem Biotechnol 126, 13–21 (2005). https://doi.org/10.1007/s12010-005-0002-8

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  • DOI: https://doi.org/10.1007/s12010-005-0002-8

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