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An Immunofluorescence–Histochemistry Study of the Nogo Receptor in the Rat Retina During Postnatal Development

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Annals of Ophthalmology

Abstract

We investigated expression of the Nogo receptor (NgR) in the retina of rats between postnatal day 0 (PND 0) and adulthood (PND 63). Frozen sections of eyeball were prepared from each of six rats on PND 0, PND 3, PND 7, PND 14, PND 21, PND 35, PND 49, and PND 63. Immunofluorescence–histochemistry and laser-confocal microscopy were used to observe the expression of NgR protein. NgR is positive in the retina at all stages. It was distributed around ganglion cell nuclei and disposed linearly in the optic nerve. The NgR was expressed in rat retina at the time of birth and was present throughout postnatal development.

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Acknowledgement

Foundation item: National Natural Science Foundation of China (No. 30572009).

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Authors and Affiliations

  1. Department of Ophthalmology, Daping Hospital, Third Military Medical University, 10, Changjiang Zhilu, Daping, Chongqing, 400042, China

    Yin Xiaolei PhD, Chen Chunlin PhD, Yuan Rongdi MD & Ye Jian MD

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  1. Yin Xiaolei PhD
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  2. Chen Chunlin PhD
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  3. Yuan Rongdi MD
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  4. Ye Jian MD
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Corresponding author

Correspondence to Ye Jian MD.

Additional information

Drs. Xiaolei, Jian, Chunlin, and Rongdi are from the Third Military Medical University, Department of Ophthalmology, Daping Hospital, Chongqing, China. E-mail: yinxiaolei971221@163.com

The authors have stated they do not have a significant financial interest or other relationship with any product manufacturer or provider of services discussed in this article. The authors also do not discuss the use of off-label products, which includes unlabeled, unapproved, or investigative products or devices.

We investigated Nogo receptor (NgR) expression in the retina of rats from postnatal day 0 to adulthood.

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Xiaolei, Y., Chunlin, C., Rongdi, Y. et al. An Immunofluorescence–Histochemistry Study of the Nogo Receptor in the Rat Retina During Postnatal Development. Ann Ophthalmol 39, 140–144 (2007). https://doi.org/10.1007/s12009-007-0001-1

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  • DOI: https://doi.org/10.1007/s12009-007-0001-1

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