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Polyelectrolytes fabrication on magnesium alloy surface by layer-by-layer assembly technique with antiplatelet adhesion and antibacterial activities

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Abstract

Magnesium alloy (MgA) was widely used in biomedical field owing to its good biocompatibility and degradability. The surface of MgA was usually modified to improve its corrosion resistance, biocompatibility, and biological properties. Herein, we employed a layer-by-layer assembly technique to assemble both polyanionic and polycationic electrolytes onto the microarc oxidation-treated MgA surface to yield MgA-MgO-PEI-[Ge(HANPs)/Lzm]50, where the gelatin-conjugated hydroxyapatite nanoparticles [Ge(HANPs)] are the polyanionic electrolyte, lysozyme (Lzm) is the polycationic electrolyte, and polyethyleneimine (PEI) is the transition layer. The morphology and chemical composition of MgA-MgO-PEI-[Ge(HANPs)/Lzm]50 were characterized by X-ray diffraction, scanning electron microscopy, and X-ray photoelectron spectroscopy, indicating that [Ge(HANPs)/Lzm]50 were successfully fabricated on the surface of MgA-MgO. The surface of MgA-MgO-PEI-[Ge(HANPs)/Lzm]50 exhibited good hydrophilicity as evidenced by the low water contact angle of 24.5°. Excellent corrosion resistance of MgA-MgO-PEI-[Ge(HANPs)/Lzm]50 was obtained since it can decrease about four orders of magnitude of corrosive current (Icorr) compared to pristine MgA. The biological assay for MgA-MgO-PEI-[Ge(HANPs)/Lzm]50 showed good antiplatelet adhesion and excellent antibacterial activities against both E. coli and S. aureus.

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Acknowledgments

This work was financially supported by the National Natural Science Foundation of China (Nos. 21773149, 21273142, 21703132), State Key Project of Research and Development (No. 2016YFC1100300), and Program for Changjiang Scholars and Innovative Research Team in University (IRT_14R33).

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Authors and Affiliations

  1. Key Laboratory of Applied Surface and Colloid Chemistry (Ministry of Education), School of Chemistry and Chemical Engineering, Shaanxi Normal University, Xi’an, 710119, China

    Mengke Peng, Xiaodan Zhang, Xiao Xiao, Mengjin Dong, Guowei Zhao, Yashao Chen & Changhao Wang

  2. Key Laboratory of Biorheological Science and Technology (Ministry of Education), College of Bioengineering, Chongqing University, Chongqing, 400044, China

    Peng Liu

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  1. Mengke Peng
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  2. Xiaodan Zhang
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  3. Xiao Xiao
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Correspondence to Yashao Chen or Changhao Wang.

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Peng, M., Zhang, X., Xiao, X. et al. Polyelectrolytes fabrication on magnesium alloy surface by layer-by-layer assembly technique with antiplatelet adhesion and antibacterial activities. J Coat Technol Res 16, 857–868 (2019). https://doi.org/10.1007/s11998-018-00162-6

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