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Advances in Rheumatoid Arthritis Animal Models

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Abstract

Experimental models of rheumatoid arthritis have contributed immensely to our understanding of the pathogenesis as well as the treatment of this debilitating autoimmune disease. Significant progress has been made in the past few years in defining the role of newer cytokines and regulatory T cells, of inflammation-mediated bone and cartilage damage, and of the cholinergic anti-inflammatory pathway in modulating the disease process in arthritis. Furthermore, new therapeutic targets, including specific tyrosine kinases and proteasome subunits, have been explored. These advances offer renewed optimism for continued improvements in the management of rheumatoid arthritis.

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Acknowledgment

This work was supported by grants (R01 AT004321 and PO1 AT002605) from the National Institutes of Health.

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No potential conflicts of interest relevant to this article were reported.

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Authors and Affiliations

  1. Department of Microbiology and Immunology, University of Maryland School of Medicine, HSF-1, Suite 380, 685 West Baltimore Street, Baltimore, MD, 21201, USA

    Kamal D. Moudgil

  2. Division of Rheumatology, UCLA School of Medicine, 1000 Veteran Avenue, Room 32-59, Los Angeles, CA, 90095-1670, USA

    Peter Kim & Ernest Brahn

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  1. Kamal D. Moudgil
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  2. Peter Kim
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  3. Ernest Brahn
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Correspondence to Ernest Brahn.

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Moudgil, K.D., Kim, P. & Brahn, E. Advances in Rheumatoid Arthritis Animal Models. Curr Rheumatol Rep 13, 456–463 (2011). https://doi.org/10.1007/s11926-011-0200-z

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