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Is There an Inflammatory Profile of Perinatal Depression?

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Abstract

Purpose of Review

To synthesize and critically examine recent evidence regarding associations between immune system activity and perinatal depression.

Recent Findings

Despite a significant number of studies assessing potential immunological markers of perinatal depression, it does not appear that levels of any individual pro- or anti-inflammatory marker is a useful predictor of perinatal depression. Some recent studies have observed differences in overall immune system functioning and adaptation across this period, taking into account multiple pro- and anti- inflammatory markers. Furthermore, there is evidence for interactions between depression and maternal psychosocial factors. Immune system functioning may be a mechanism through which social determinants of health contribute to risk for perinatal depression.

Summary

There is substantial evidence implicating dysregulated immune activity in perinatal depression, yet little clarity regarding a consistent immune profile, especially based on analysis of circulating peripheral cytokines.

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Authors and Affiliations

  1. Department of Child and Adolescent Psychiatry, New York University Langone Medical Center, New York, NY, USA

    Clare McCormack

  2. Department of Basic Sciences, College of Medicine, Princess Nourah Bint Abdulrahman University, Riyadh, Saudi Arabia

    Sameera Abuaish

  3. Departments of Obstetrics and Gynecology and Psychiatry, Columbia University Irving Medical Center, New York, NY, USA

    Catherine Monk

  4. New York State Psychiatric Institute, New York, NY, USA

    Catherine Monk

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Correspondence to Clare McCormack.

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McCormack, C., Abuaish, S. & Monk, C. Is There an Inflammatory Profile of Perinatal Depression?. Curr Psychiatry Rep 25, 149–164 (2023). https://doi.org/10.1007/s11920-023-01414-y

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