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Rapid cycling bipolar disease: New concepts and treatments

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Abstract

Having been recognized by Kraeplin at the beginning of the 20th century [1•], rapid cycling was first described as a specific entity by Dunner et al. [2,3] in 1974. The prevalence of rapid cycling ranges from 12% to 20% in patients with bipolar disorder who are not selected for a high rate of cycling [4].

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References and Recommended Reading

  1. Calabrese JR, Shelton MD, Bowden CL, et al.: Bipolar rapid cycling: focus on depression as its hallmark. Compr Psychiatry 2001, 62(suppl):34–41. A good article.

    Google Scholar 

  2. Dunner DL, Fieve RR: Clinical factors in lithium carbonate prophylaxis failure. Arch Gen Psychiatry 1974, 30:229–233.

    PubMed  CAS  Google Scholar 

  3. Dunner DL, Feiss JL, Fieve RR: The course of development of mania in patients with recurrent depression. Am J Psychiatry 1976, 133:905–908.

    PubMed  CAS  Google Scholar 

  4. Baldessarini RJ, Tondo L, Floris G, Hennen J: Effects of rapid cycling on response to lithium maintenance treatment in 360 bipolar I and II disorder patients. J Affective Disord 2000, 61:13–22.

    Article  CAS  Google Scholar 

  5. Bauer MS: Long-term treatment of rapid cycling bipolar affective disorder. Biol Psychiatry 1997, 42:201S-202S.

    Article  Google Scholar 

  6. Altschuler LL, Post RM, Leverich GS: Antidepressant-induced mania and cycle acceleration: a controversy revisited. Am J Psychiatry 1995, 152:1130–1138.

    Google Scholar 

  7. Post RM: Approaches to treatment-resistant bipolar affectively ill patients. Clinical Neuropharmacology 1988, 11:93–104.

    Article  PubMed  CAS  Google Scholar 

  8. Maj M, Pirozzi R, Formicola AM, Tortorella A: Reliability and validity of four alternative definitions of rapid-cycling bipolar disorder. Am J Psychiatry 1999, 156:1421–1424. A very important paper describing alternate definitions of rapid cycling bipolar disorder.

    PubMed  CAS  Google Scholar 

  9. Roy-Byrne PP, Joffe RT, Uhde TW, Post RM: Approaches to the evaluation and treatment of rapid-cycling affective illness. Br J Psychiatry 1984, 145:543–550.

    PubMed  CAS  Google Scholar 

  10. Kramlinger KG, Post RM: Ultra-rapid and ultradian cycling in bipolar affective illness. Br J Psychiatry 1996, 168:314–323.

    PubMed  CAS  Google Scholar 

  11. Kilzich N, Akiskal HS: Rapid cycling bipolar disorder: an overview. Psychiatr Clin North Am 1999, 22:585–607.

    Article  Google Scholar 

  12. Akiskal HS: The prevalent clinical spectrum of bipolar disorders: beyond DSM-IV. J Clin Psychopharmacol 1996, 16(suppl):4S-14S. Excellent paper providing information beyond DSM-IV.

    Article  PubMed  CAS  Google Scholar 

  13. Post RM, Kramlinger KG, Altshuler LL, et al.: Treatment of rapid cycling bipolar illness. Psychopharmacol Bull 1990, 26:37–47.

    PubMed  CAS  Google Scholar 

  14. Pazzaglia PJ, Post RM, Ketter TA, et al.: Preliminary controlled trial of nimodipine in ultra-rapid cycling affective dysregulation. Psychiatry Res 1993, 49:257–272.

    Article  PubMed  CAS  Google Scholar 

  15. Freeman MP, McElroy SL: Clinical picture and etiologic models of mixed states. Psychiatr Clin North Am 1999, 22:535–546.

    Article  PubMed  CAS  Google Scholar 

  16. Akiskal HS, Bourgeois ML, Angst J, et al.: Re-evaluating the prevalence of and diagnostic composition within the broad clinical spectrum of bipolar disorders. J Affective Disord 2000, 59(suppl):S5-S30. Another superb paper by Akiskal and colleagues.

    Article  Google Scholar 

  17. Bowden CL, Calabrese JR, McElroy SL, et al.: The efficacy of lamotrigine in rapid cycling and non-rapid cycling patients with bipolar disorder. Biol Psychiatry 1999, 45:953–958.

    Article  PubMed  CAS  Google Scholar 

  18. Maj M, Magliano L, Pirozzi R, et al.: Is rapid cycling a valid subtype of bipolar disorder? Eur Neuopsychopharmacol 1995, 5:228–232.

    Article  Google Scholar 

  19. Tomitaka and Sakamoto 1994.

  20. Kilzieh N, Akiskal HS: Rapid-cycling bipolar disorder: An overview of research and clinical experience. Psychiatr Clin North Am 2000, 22:585–607.

    Article  Google Scholar 

  21. Nurnberger J, Guroff JJ, Hannovit J, et al.: A family study of rapid-cycling bipolar illness. J Affective Disord 1988, 15:87–91.

    Article  Google Scholar 

  22. Lish JD, Gyulai L, Resnick SM, et al.: A family history study of rapid-cycling bipolar disorder. Psychiatry Res 1993, 48:37–46.

    Article  PubMed  CAS  Google Scholar 

  23. Goodwin FK, Wirz-Justice A, Wehr TA: Evidence that the pathophysiology of depression and the mechanism of antidepressant drugs both involve alterations in circadian rhythms. Adv Biochem Psychopharmacol 1982, 32:1–11.

    PubMed  CAS  Google Scholar 

  24. Wehr T, Sack D, Rosenthal N, Cowdry R: Rapid cycling affective disorder: contributing factors and treatment responses in 51 patients. Am J Psychiatry 1988, 145:179–184.

    PubMed  CAS  Google Scholar 

  25. Wehr T: Can antidepressants induce rapid cycling? Arch. Gen. Psychiatry 1993, 50:495–496.

    PubMed  CAS  Google Scholar 

  26. Roy-Byrne PP, Post RM, Uhde TW, et al.: The longitudinal course of recurrent affective illness: life chart data from research patients at the NIMH. Acta Psychiatr Scand Suppl 1985, 317:1–34.

    PubMed  CAS  Google Scholar 

  27. Akiskal HS: Chronic depression. Bull Menninger Clin 1991, 240:349–354.

    Google Scholar 

  28. Scott J: Chronic depression. Br. J. Psychiatry 1988, 153:287–297.

    PubMed  CAS  Google Scholar 

  29. Bauer MS, Whybrow PC, Winokur A: Rapid cycling bipolar affective disorder, I: association with grade I hypothyroidism. Arch Gen Psychiatry 1990, 47:427–432.

    PubMed  CAS  Google Scholar 

  30. Cowdry RW, Wehr TA, Zis AP, Goodwin FK: Thyroid abnormalities associated with rapid-cycling bipolar illness. Arch Gen Psychiatry 1983, 40:414–420.

    PubMed  CAS  Google Scholar 

  31. Terao T: Subclinical hypothyroidism in recurrent mania. Biol Psychiatry 1993, 33:853–854.

    Article  PubMed  CAS  Google Scholar 

  32. Post RM, Kramlinger KG, Joffe RT, et al.: Rapid cycling bipolar affective disorder: lack of relation to hypothyroidism. Psychiatry Res 1997, 72:1–7.

    Article  PubMed  CAS  Google Scholar 

  33. Wirz-Justice A, Quinto C, Cajochen C, et al.: A rapid-cycling bipolar patient treated with long nights, bedrest, and light. Biol Psychiatry 1999, 45:1075–1077.

    Article  PubMed  CAS  Google Scholar 

  34. Ashman SB, Mont TH, Kupfer DJ, et al.: Relationship between social rhythms and mood in patients with rapid cycling bipolar disorder. Psychiatry Res 1999, 86:1–8. A good article.

    Article  PubMed  CAS  Google Scholar 

  35. Leibenluft E, Albert PS, Rosenthal NE, Wehr T: Relationship between sleep and mood in patients with rapid-cycling bipolar disorder. Psychiatry Res 1996, 63:161–168.

    Article  PubMed  CAS  Google Scholar 

  36. Post RM, Ketter TA, Pazzaglia PJ, et al.: Rational polypharmacy in the bipolar affective disorders. Epilepsy Res 1996, 11(suppl):153–180.

    CAS  Google Scholar 

  37. Post RM: Transduction of psychosocial stress into the neurobiology of recurrent affective disorder. Am J Psychiatry 1992, 149:999–1010.

    PubMed  CAS  Google Scholar 

  38. Post RM, Rubinow DR, Ballenger JC: Conditioning and sensitization in the longitudinal course of affective illness. Br J Psychiatry 1986, 149:191–201.

    PubMed  CAS  Google Scholar 

  39. Huber MT, Braun HA, Krieg JC: On the impact of episode sensitization on the course of recurrent affective disorders. J Psychiatr Res 2001, 35:49–57.

    Article  PubMed  CAS  Google Scholar 

  40. D’Aquila PS, Peana AT, Tanda O, Sera G: Carbamazepine prevents imipramine-induced behavioural sensitization to the dopamine D(2)-like receptor agonist quinpirole. Eur J Pharmacol 2001, 416:107–111.

    Article  PubMed  CAS  Google Scholar 

  41. Dubovsky SL, Murphy J, Christiano J, Lee C: The calcium second messenger system in bipolar disorders: data supporting new research directions. J Neuropsychiatry Clin Neurosci 1992, 4:3–14.

    PubMed  CAS  Google Scholar 

  42. Dubovsky SL, Christiano J, Daniell LC: Increased platelet intracellular calcium concentration in patients with bipolar affective disorders. Arch Gen Psychiatry 1989, 46:632–638.

    PubMed  CAS  Google Scholar 

  43. Dubovsky SL, Lee C, Christiano J: Elevated intracellular calcium ion concentration in bipolar depression. Biol Psychiatry 1991, 29:441–450.

    Article  PubMed  CAS  Google Scholar 

  44. Dubovsky SL, Lee C, Christiano J: Lithium decreases platelet intracellular calcium ion concentrations in bipolar patients. Lithium 1991, 2:167–174.

    CAS  Google Scholar 

  45. Dubovsky SL, Murphy J, Thomas M, Rademacher J: Abnormal intracellular calcium ion concentration in platelets and lymphocytes of bipolar patients. Am J Psychiatry 1992, 149:118–120.

    PubMed  CAS  Google Scholar 

  46. Tan CH, Javors MA, Seleshi E: Effects of lithium on platelet ionic intracellular calcium concentration in patients with bipolar (manic-depressive) disorder and healthy controls. Life Sci 1990, 46:1175–1180.

    Article  PubMed  CAS  Google Scholar 

  47. Dubovsky SL, Murphy J, Thomas M, Rademacher J: Abnormal intracellular calcium ion concentration in platelets and lymphocytes of bipolar patients. Am J Psychiatry 1992, 149:118–120.

    PubMed  CAS  Google Scholar 

  48. Okamoto Y, Kagaya A, Shinno H, et al.: Serotonin-induced platelet calcium mobilization is enhanced in mania. Life Sci 1995, 56:327–332.

    Article  PubMed  CAS  Google Scholar 

  49. Avissar S, Schreiber G: The involvement of guanine nucleotide binding proteins in the pathogenesis and treatment of affective disorders. Biol Psychiatry 1992, 31:435–459.

    Article  PubMed  CAS  Google Scholar 

  50. Friedman E, Wang HY, Levinson D, et al.: Altered platelet protein kinase C activity in bipolar affective disorder, manic episode. Biol Psychiatry 1993, 33:520–525.

    Article  PubMed  CAS  Google Scholar 

  51. Jope RS, Williams MB: Lithium and brain signal transduction systems. Biochem Pharmacol 1994, 47:429–441.

    Article  PubMed  CAS  Google Scholar 

  52. Mathews R, Li PP, Young T, et al.: Increased Gaq/11 immunoreactivity in postmortem occipital cortex from patients with bipolar affective disorder. Biol Psychiatry 1997, 41:649–656.

    Article  PubMed  CAS  Google Scholar 

  53. Schreiber G, Avissar S: G proteins as a biochemical tool for diagnosis and monitoring treatments of mental disorders. Isr Med Assoc J 2000, 2(suppl):86–91.

    PubMed  Google Scholar 

  54. Shelton RC: Intracellular mechanisms of antidepressant drug action. Harv Rev Psychiatry 2000, 8:161–174.

    Article  PubMed  CAS  Google Scholar 

  55. Loman N, Johannsson O, Kristoffersson U, et al.: Family history of breast and ovarian cancers and BRCA1 and BRCA2 mutations in a population-based series of early-onset breast cancer. J Natl Cancer Inst 2001, 93:1215–1223.

    Article  PubMed  CAS  Google Scholar 

  56. Roy D, Calaf G, Hei TK: Profiling of differentially expressed genes induced by high linear energy transfer radiation in breast epithelial cells. Mol Carcinog 2001, 31:192–203.

    Article  PubMed  CAS  Google Scholar 

  57. Talapatra S, Thompson CB: Growth factor signaling in cell survival: implications for cancer treatment. JPET 2001, 298:873–878.

    CAS  Google Scholar 

  58. Sun M, Paciga JE, Feldman RI, et al.: Phosphatidylinositol-3-OH kinase (PI3K)/AKT2, activated in breast cancer, regulates and is induced by estrogen receptor alpha (ERalpha) via interaction between ERalpha and P13K. Cancer Res 2001, 61:5985–5991. A good review.

    PubMed  CAS  Google Scholar 

  59. Welsh JB, Sapinoso LM, Su AI, et al.: Analysis of gene expression identifies candidate markers and pharmacological targets in prostate cancer. Cancer Res 2001, 61:5974–5978.

    PubMed  CAS  Google Scholar 

  60. Keshelava N, Zao JJ, Chen P, et al.: Loss of p53 function confers high level multidrug resistance in neuroblastoma cell lines. Cancer Res 2001, 61:6185–6195.

    PubMed  CAS  Google Scholar 

  61. Pruitt K, Der CJ: Ras and Rho regulation of the cell cycle and oncogenesis. Cancer Lett 2001, 171:1–10.

    Article  PubMed  CAS  Google Scholar 

  62. Widschwendler M, Berger J, Muller HM, et al.: Epigenetic down regulation of the retinoic acid receptor-beta 2 gene in breast cancer. J Mammary Gland Biol Neoplasia 2001, 6:193–201.

    Article  Google Scholar 

  63. Lal A, Peters H, St. Croix B, et al.: Transcriptional response to hypoxia in human tumors. J Natl Cancer Inst 2001, 93:1337–1343.

    Article  PubMed  CAS  Google Scholar 

  64. Mielnicki LM, Asch HL, Asch BB: Genes, chromatin, and breast cancer: an epigenetic tale. J Mammary Gland Biol Neoplasia 2001, 6:169–182.

    Article  PubMed  CAS  Google Scholar 

  65. Sakorafus GH, Tsiotos GG: Molecular biology of pancreatic cancer-potential clinical implications. Biodrugs 2001, 15:439–452.

    Article  Google Scholar 

  66. West M, Blanchette C, Dressman H, et al.: Predicting the clinical status of human breast cancer by using gene expression profiles. Proc Natl Acad Sci U S A 2001, 98:11462–11467.

    Article  PubMed  CAS  Google Scholar 

  67. Dubovsky SL, Murphy J, Christiano J, Lee C: The calcium second messenger system in bipolar disorders: data supporting new research directions. J Neuropsychiatry Clin Neurosci 1992, 4:3–14.

    PubMed  CAS  Google Scholar 

  68. Wang JF, Bown CD, Chen B, Young LT: Identification of mood stabilizer-regulated genes by differential display PCR. Int J Neuropsychopharmacol 2001, 4:65–74. Ecellent review.

    Article  PubMed  CAS  Google Scholar 

  69. Manji HK, Bebchuk JM, Moore GJ, et al.: Modulation of CNS signal transduction pathways and gene expression by moodstabilizing agents: therapeutic implications. J Clin Psychiatry 1999, 60(suppl):27–39.

    PubMed  Google Scholar 

  70. Moore GJ, Bebchuk JM, Hasanat K, et al.: Lithium increases N-acetyl-aspartate in the human brain: in vivo evidence in support of bcl-2′s neurotrophic effects? Biol Psychiatry 2000, 48:1–8. A good review.

    Article  PubMed  CAS  Google Scholar 

  71. Chen G, Masana MI, Manji HK: Lithium regulates PKCmediated intracellular cross-talk and gene expression in the CNS in vivo. Bipolar Disorders 2000, 2:217–236.

    Article  PubMed  CAS  Google Scholar 

  72. Berk M: Lamotrigine and the treatment of mania in bipolar disorder. Eur Neuropsychopharmacol 1999, 9:119–123.

    Article  Google Scholar 

  73. Xie X, Hagan RM: Cellular and molecular actions of lamotrigine: possible mechanisms of efficacy in bipolar disorder. Neuropsychobiology 1998, 38:119–130.

    Article  PubMed  CAS  Google Scholar 

  74. Avissar S, Schreiber G: Interaction of antibipolar and antidepressant treatments with receptor-coupled G proteins. Pharmacopsychiatry 1992, 25:44–50.

    PubMed  CAS  Google Scholar 

  75. Cole AJ, Scott J, Ferrier IN, Eccleston D: Patterns of treatment resistance in bipolar affective disorder. Acta Psychiatr Scand 1993, 88:121–123.

    PubMed  CAS  Google Scholar 

  76. Kusumaker V, Yatham LN, Haslam DRS, et al.: Treatment of mania, mixed state, and rapid cycling. Can J Psychiatry 1997, 42(suppl):79S-86S.

    Google Scholar 

  77. Gershon ES, Soares JC: Current therapeutic profile of lithium. Arch Gen Psychiatry 1997, 54:16–18.

    PubMed  CAS  Google Scholar 

  78. Kleindiest N, Greil W: Differential efficacy of lithium and carbamazepine in the prophylaxis of bipolar disorder: results of the MAP study. Neuropsychobiology 2000, 42(suppl):2–10.

    Article  Google Scholar 

  79. Okuma T: Effects of carbamazepine and lithium on affective disorders. Neuropsychobiology 1993, 27:138–145.

    Article  PubMed  CAS  Google Scholar 

  80. Schneider AL, Wilcox CS: Divalproate augmentation in lithium-resistant rapid cycling mania in four geriatric patients. J Affective Disord 1998, 47:201–205.

    Article  CAS  Google Scholar 

  81. Schaff MR, Fawcett J, Zajecka J: Divalproex sodium in the treatment of refractory affective disorders. Compr Psychiatry 1993, 54:380–384.

    CAS  Google Scholar 

  82. Expert Consensus Panel: Treatment of bipolar disorder. Compr Psychiatry 1996, 57(suppl):1–88.

    Google Scholar 

  83. Bowden CL, Lecrubier Y, Bauer MS, et al.: Maintenance therapies for classic and other forms of bipolar disorder. J Affective Disord 2000, 59(suppl):S57-S67. A good review.

    Article  Google Scholar 

  84. Bowden CL, Brugger AM, Swann AC: Efficacy of divalproex vs lithium in the treatment of mania. JAMA 1994, 271:918–924.

    Article  PubMed  CAS  Google Scholar 

  85. Walden J, Schaerer L, Schloesser S, Grunze H: An open longitudinal study of patients with bipolar rapid cycling treated with lithium or lamotrigine for mood stabilization. Bipolar Disord 2000, 2:336–339.

    Article  PubMed  CAS  Google Scholar 

  86. Calabrese JR, Suppes T, Bowden CL, et al.: A double-blind, placebo-controlled, prophylaxis study of lamotrigine in rapid-cycling bipolar disorder. Compr Psychiatry 2000, 61:841–850.

    CAS  Google Scholar 

  87. Bowden CL, Calabrese JR, Rapaport M, et al.: Lamotrigine demonstrates long term mood stabilization in recently manic patients. Paper presented at Annual Meeting of the New Clinical Drug Evaluation Unit (NCDEU); Phoenix, AZ. May 28–31, 2001;

  88. Post RM, Frye MA, Denicoff KD, et al.: Emerging trends in the treatment of rapid cycling bipolar disorder: a selected review. Bipolar Disord 2000, 2:305–315.

    Article  PubMed  CAS  Google Scholar 

  89. Brunet G, Cerlich B, Robert P: Open trial of a calcium antagonist, nimodipine, in acute mania. Clin Neuropharmacol 1990, 13:224–228.

    Article  PubMed  CAS  Google Scholar 

  90. Goodnick PJ: The use of nimodipine in the treatment of mood disorders. Bipolar Disord 2000, 2:165–173.

    Article  PubMed  CAS  Google Scholar 

  91. Davanzo PA, Krah N, Kleiner J, McCracken J: Nimodipine treatment of an adolescent with ultradian cycling bipolar affective illness. J Child Adolesc Psychopharmacol 1999, 9:51–61.

    Article  PubMed  CAS  Google Scholar 

  92. Manna V: Disturbi affectivi bipolari e ruolo del calcio intraneuronale. Effetti terapeutici del trattamento con cali di litio e/o calcio antagonista in pazienti con rapida inversione di polarita. Minerva Medicine 1991, 82:757–763.

    CAS  Google Scholar 

  93. Pazzaglia PJ, Post RM, Ketter TA, et al.: Nimodipine monotherapy and carbamazepine augmentation in patients with refractory recurrent affective illness. J Clin Psychopharmacol 1998, 18:404–413.

    Article  PubMed  CAS  Google Scholar 

  94. Banov MD, Zarate CA, Tohen M, et al.: Clozapine therapy in refractory affective disorders: polarity predicts response in long-term follow-up. J Clin Psychiatry 1994, 55:295–300.

    PubMed  CAS  Google Scholar 

  95. Calabrese JR, Meltzer HY, Markovitz PJ: Clozapine prophylaxis in rapid cycling bipolar disorder. J Clin Psychopharmacol 1991, 11:396–397.

    Article  PubMed  CAS  Google Scholar 

  96. Calabrese JR, Fatemi SH, Woyshville MJ: Antidepressant effects of lamotrigine in rapid cycling bipolar disorder [letter]. Am J Psychiatry 1996, 153:1236.

    PubMed  CAS  Google Scholar 

  97. Frye M, Altschuler LL, Bitran JE: Clozapine in rapid cycling bipolar disorder [letter]. J Clin Psychopharmacol 1996, 16:87–90.

    Article  PubMed  CAS  Google Scholar 

  98. Klapheke MM: Clozapine, ECT, and schizoaffective disorder, bipolar type. Convuls Ther 1991, 7:36–39.

    PubMed  Google Scholar 

  99. McElroy SL, Dessain EC, Pope HG, et al.: Clozapine in the treatment of psychotic mood disorders, schizoaffective disorder, and schizophrenia. J Clin Psychiatry 1991, 52:411–414.

    PubMed  CAS  Google Scholar 

  100. Small JG, Klapper MH, Milstein V, et al.: Comparison of therapeutic modalities for mania. Psychopharmacol Bull 1996, 32:516.

    Google Scholar 

  101. Suppes T, McElroy SL, Gilbert J, et al.: Clozapine in the treatment of dysphoric mania. Biol Psychiatry 1992, 32:270–280.

    Article  PubMed  CAS  Google Scholar 

  102. Zarate CA, Tohen M, Banov MD, et al.: Is clozapine a mood stabilizer? J Clin Psychiatry 1995, 56:108–112.

    PubMed  Google Scholar 

  103. Ghaemi SN, Goodwin FK: Use of atypical antipsychotic agents in bipolar and schizoaffective disorders: review of the empirical literature. J Clin Psychopharmacol 1999, 19:354–361.

    Article  PubMed  CAS  Google Scholar 

  104. Suppes T, Phillips KA, Judd CR: Clozapine treatment of nonpsychotic rapid cycling bipolar disorder: a report of three cases. Biol Psychiatry 1994, 36:338–340.

    Article  PubMed  CAS  Google Scholar 

  105. Green AI, Tohen M, Patel JK, et al.: Clozapine in the treatment of refractory psychotic mania. Am J Psychiatry 2000, 157:982–986.

    Article  PubMed  CAS  Google Scholar 

  106. Suppes T, Webb A, Paul B, et al.: Clinical outcome in a randomized 1-year trial of clozapine versus treatment as usual for patients with treatment-resistant illness and a history of mania. Am J Psychiatry 1999, 156:1164–1169.

    PubMed  CAS  Google Scholar 

  107. Madhusoodanan S, Brenner R, Araujo L, Abaza A: Efficacy of risperidone treatment for psychoses associated with schizophrenia, schizoaffective disorder, bipolar disorder, or senile dementia in 11 geriatric patients: a case series. J Clin Psychiatry 1995, 56:514–518.

    PubMed  CAS  Google Scholar 

  108. Singh AN, Catalan J: Risperidone in HIV-related manic psychosis. Lancet 1994, 344:1029–1030.

    Article  PubMed  CAS  Google Scholar 

  109. Tohen M, Zarate CA, Centorrino F, et al.: Risperidone in the treatment of mania. J Clin Psychiatry 1996, 57:249–253.

    PubMed  CAS  Google Scholar 

  110. Tohen M, Zarate CA, Centorrino F, et al.: Risperidone in the treatment of mania [abstract]. Psychopharmacol Bull 1996, 31:626.

    Google Scholar 

  111. Tohen M, Sanger TM, McElroy SL, et al.: Olanzapine versus placebo in the treatment of acute mania. Am J Psychiatry 1999, 156:702–709.

    PubMed  CAS  Google Scholar 

  112. Tohen M, Jacobs TG, Grundy SL, et al.: Efficacy of olanzapine in acute bipolar mania: a double-blind, placebo-controlled study. The Olanzapine HGGW Study Group. Arch Gen Psychiatry 2000, 57:841–849.

    Article  PubMed  CAS  Google Scholar 

  113. Berk M, Ichim L, Brook L: Olanzapine compared to lithium in mania: a double-blind randomized controlled trial. Int Clin Psychopharmacol 1999, 14:339–342.

    Article  PubMed  CAS  Google Scholar 

  114. Anonymous: Atypical antipsychotics for treatment of depression in schizophrenia and affective disorders. Collaborative Working Group on Clinical Trial Evaluations. J Clin Psychiatry 1998, 59(suppl):41–45.

    Google Scholar 

  115. Borysewicz K, Borysewicz W: A case of mania follwoing olanzapine administration. Psychiatria Polska 2000, 34:299–306.

    PubMed  CAS  Google Scholar 

  116. Simon AE, Aubry JM, Malky L, Bertschy G: Hypomania-like syndrome induced by olanzapine. Int Clin Psychopharmacol 1999, 14:377–378.

    Article  PubMed  CAS  Google Scholar 

  117. Fitz-Gerald MJ, Pinkofsky HB, Brannon G, et al.: Olanzapineinduced mania [letter]. Am J Psychiatry 1999, 156:1114.

    PubMed  CAS  Google Scholar 

  118. Benazzi F: Olanzapine-induced psychotic mania in bipolar schizoaffective disorder [letter]. Eur Psychiatry 1999, 14:410–411.

    Article  PubMed  CAS  Google Scholar 

  119. John V, Rapp M, Pies R: Aggression, agitation, and mania with olanzapine [letter]. Can J Psychiatry 1998, 43:1054.

    PubMed  CAS  Google Scholar 

  120. Pozo P, Aleantara AG: Mania-like syndrome in a patient with chronic schizophrenia during olanzapine treatment [letter]. J Psychiatry Neurosci 1998, 23:309–310.

    PubMed  CAS  Google Scholar 

  121. Reeves RR, McBride WA, Brannon GE: Olanzapine-induced mania (letter). J Am Osteopath Assoc 1998, 98:550.

    Google Scholar 

  122. Lindenmayer JP, Klebanov R: Olanzapine-induced manic-like syndrome [letter]. J Clin Psychiatry 1998, 59:318–319.

    PubMed  CAS  Google Scholar 

  123. London JA: Mania associated with olanzapine [letter]. J Am Acad Child Adol Psychiatry 1998, 37:135–136.

    Article  CAS  Google Scholar 

  124. Solhkhah R, Finkel J, Hird S: Possible risperidone-induced visual hallucinations [letter]. J Am Acad Child Adol Psychiatry 2000, 39:1074–1075.

    Article  CAS  Google Scholar 

  125. Mayerhoff D, Vital-Herne J, Lesser M, Brenner R: Alprazolaminduced manic reaction. N Y State J Med 1986, 86:320.

    PubMed  CAS  Google Scholar 

  126. Cole JO, Kando JC: Adverse behavioral events reported in patients taking alprazolam and other benzodiazepines. Compr Psychiatry 1995, 54(suppl):49–61.

    Google Scholar 

  127. Bauer M, Hellweg R, Baumgartner A: High dosage thyroxine treatment in therapy and prevention refractory patients with affective psychoses. Nervenarzt 1998, 69:1019–1022.

    Article  PubMed  CAS  Google Scholar 

  128. Gjessing LR: Disturbances of somatic function in catatonia with a periodic course and their compensation. J Ment Sci 1938, 84:608–621.

    CAS  Google Scholar 

  129. Stancer HC, Persad E: Treatment of intractable rapid-cycling manic-depressive disorder with levothyroxine: clinical observations. Arch Gen Psychiatry 1982, 39:311–312.

    PubMed  CAS  Google Scholar 

  130. Afflelou S, Auriacombe M, Cazenave M, et al.: High dose levothyroxine for treatment of rapid cycling bipolar disorder: Review of the literature and application to 6 subjects. Encephale 1997, 23:209–217.

    PubMed  CAS  Google Scholar 

  131. Bauer MS, Whybrow PC: Rapid cycling bipolar affective disorder. II. Treatment of refractory rapid cycling with highdose levothyroixine: a preliminary study. Arch Gen Psychiatry 1990, 47:435–440.

    PubMed  CAS  Google Scholar 

  132. Bernstein L: Abrupt cessation of rapid-cycling bipolar disorder with the addition of low-dose L-tetraiodothyronine to lithium. J Clin Psychopharmacol 1992, 12:443–444.

    Article  PubMed  CAS  Google Scholar 

  133. Bauer MS, Whybrow PC: The effect of changing thyroid function on cyclic affective illness in a human subject. Am J Psychiatry 1986, 143:636.

    Google Scholar 

  134. Extein I, Pottash ALC, Gold MS: Does subclinical hypothyroidism predispose to tricyclic-induced rapid mood cycles. J Clin Psychiatry 1982, 43:290–291.

    PubMed  CAS  Google Scholar 

  135. Cooper DE: Subclinical hypothyroidism. N Engl J Med 2001, 345:260–265.

    Article  PubMed  CAS  Google Scholar 

  136. Hopkins HS, Gelenberg AJ: Treatment of bipolar disorder: how far have we come? Psychopharmacol Bull 1994, 30:27–38.

    PubMed  CAS  Google Scholar 

  137. Bergsholm P, Martinsen EW, Svoen N, et al.: Affective disorders. Drug treatment and electroconvulsive therapy. Tidsskr Nor Laegeforen 1992, 112:2651–2656.

    PubMed  CAS  Google Scholar 

  138. Zornberg GL, Pope HG: Treatment of depression in bipolar disorder: new directions for research. J Clin Psychopharmacol 1993, 13:397–408.

    Article  PubMed  CAS  Google Scholar 

  139. Mukherjee S, Sackeim HA, Schnur DB: Electroconvulsive therapy of acute manic episodes: a review of 50 years’ experience. Am J Psychiatry 1994, 151:169–176.

    PubMed  CAS  Google Scholar 

  140. Berman E, Wolpert EA: Intractable manic-depressive psychosis with rapid cycling in an 18-year-old woman successfully treated with electroconvulsive therapy. J Nerv Ment Dis 1987, 175:236–239.

    Article  PubMed  CAS  Google Scholar 

  141. Mosolov SN, Moshchevitin SL: Use of electroconvulsive therapy for breaking the continuous course of drug-resistant affective and schizoaffective psychoses. Zhurnal Nevropatologii i Psikhiatrii Imeni S-S Korsakova 1990, 90:121–125.

    PubMed  CAS  Google Scholar 

  142. Wolpert EA, Berman V, Bernstein M: Efficacy of electroconvulsive therapy in continuous rapid cycling bipolar disorder. Psychiatr Ann 1999, 29:679–683.

    Google Scholar 

  143. Fink M: Indications for the use of ECT. Psychopharmacol Bull 1995, 30:269–275.

    Google Scholar 

  144. Milstein V, Small JG, Klapper MH: Uni-versus bilateral ECT in the treatment of mania. Convuls Ther 1987, 3:1–9.

    PubMed  Google Scholar 

  145. Small JG, Small IF, Milstein V: Manic symptoms: an indication for bilateral ECT. Biol Psychiatry 1985, 20:125–134.

    Article  PubMed  CAS  Google Scholar 

  146. Schnur DB, Mukherjee S, Sackeim HA, et al.: Symptomatic predictors of ECT response in medication-nonresponsive bipolar illness. J Clin Psychiatry 1992, 53:63–66.

    PubMed  CAS  Google Scholar 

  147. Swoboda E, Conca A, Konig P, et al.: Maintenance electroconvulsive therapy in affective and schizoaffective disorder. Neuropsychobiology 2001, 43:23–28.

    Article  PubMed  CAS  Google Scholar 

  148. Goodwin FK, Wirz-Justice A, Wehr TA: Evidence that the pathophysiology of depression and the mechanism of antidepressant drugs both involve alterations in circadian rhythms. Adv Biochem Psychopharmacol 1982, 32:1–11.

    PubMed  CAS  Google Scholar 

  149. Kusumi I, Ohmori T, Kohsaka M, et al.: Chronobiological approach for treatment-resistant rapid cycling affective disorders. Biol. Psychiatry 1995, 37:553–559.

    Article  PubMed  CAS  Google Scholar 

  150. Stoll AL, Sachs GS, Cohen BM, et al.: Choline in the treatment of rapid-cycling bipolar disorder: clinical and neurochemical findings in lithium-treated patients. Biol. Psychiatry 1996, 40:382–388.

    Article  PubMed  CAS  Google Scholar 

  151. Hayes SG: Acetazolamide in bipolar affective disorders. Ann Clin Psychiatry 2001, 6:91–98.

    Google Scholar 

  152. Post RM: Comparative pharmacology of bipolar disorder and schizophrenia. Schizophr Res 1999, 39:153–158.

    Article  PubMed  CAS  Google Scholar 

  153. Post RM, Frye MA, Denicoff K, et al.: Beyond lithium in the treatment of bipolar illness. Neuropsychobiology 1998, 19:206–219.

    CAS  Google Scholar 

  154. Grisaru N, Chudakov B, Yaroslavosky Y, Belmaker RH: Transcranial magnetic stimulation in mania: a controlled study. Am J Psychiatry 1998, 155:1608–1610. A good review.

    PubMed  CAS  Google Scholar 

  155. Ghaemi SN, Gaughan S: Novel anticonvulsants: a new generation of mood stabilizers? Harv Rev Psychiatry 2000, 8:1–7.

    Article  PubMed  CAS  Google Scholar 

  156. Calabrese JR, Bowden CL, McElroy SL, et al.: Spectrum of activity of lamotrigine in treatment-refractory bipolar disorder. Am J Psychiatry 1999, 156:1019–1023.

    PubMed  CAS  Google Scholar 

  157. Calabrese JR, Bowden CL, Sachs GS, et al.: A double-blind placebo-controlled study of lamotrigine monotherapy in outpatients with bipolar I depression. Lamictal 602 Study Group. J Clin Psychiaty 1999, 60:79–88.

    Article  CAS  Google Scholar 

  158. Healy E, Mckeon P: Rapid cycling mood disorder: a review. Ir J Psychol Med 1997, 14:26–31.

    Google Scholar 

  159. Montaner JSG, Mellors JW: Antiretroviral therapy for previously treated patients. N Engl J Med 2001, 345:452–454.

    Article  PubMed  CAS  Google Scholar 

  160. Albrecht MA, Bosch RJ, Hammer SM, et al.: Nelfinavir, efavirenz, or both after the failure of nucleoside treatment of HIV infection. N Engl J Med 2001, 345:398–407.

    Article  PubMed  CAS  Google Scholar 

  161. Sachs GS, Printz DJ, Kahn DA, et al.: The Expert Consensus Guideline Series: medication treatment of bipolar disorder 2000. Postgrad Med 2000, Spec No:pp1–104.

  162. Frances AJ, Kahn DA, Carpenter D, et al.: The Expert Consensus Guidelines for treating depression in bipolar disorder. J Clin Psychiatry 1998, 59(suppl):73–79. A good review.

    PubMed  Google Scholar 

  163. Moller H-J, Grunze H: Have some guidelines for the treatment of acute bipolar depression gone too far in the restriction of antidepressants? Eur Arch Psychiatry Clin Neurosci 2000, 25:57–68.

    Google Scholar 

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  1. Departments of Psychiatry and Medicine, University of Colorado School of Medicine, 4200 East 9th Avenue, 80262, Denver, CO, USA

    Steven L. Dubovsky MD

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Dubovsky, S.L. Rapid cycling bipolar disease: New concepts and treatments. Curr Psychiatry Rep 3, 451–462 (2001). https://doi.org/10.1007/s11920-001-0038-6

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