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Biomechanical Properties of Metastatically Involved Osteolytic Bone

  • Biomechanics (G Niebur and J Wallace, Section Editors)
  • Published:
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Abstract

Purpose of Review

Skeletal metastasis involves the uncoupling of physiologic bone remodeling resulting in abnormal bone turnover and radical changes in bony architecture, density, and quality. Bone strength assessment and fracture risk prediction are critical in clinical treatment decision-making. This review focuses on bone tissue and structural mechanisms altered by osteolytic metastasis and the resulting changes to its material and mechanical behavior.

Recent Findings

Both organic and mineral phases of bone tissue are altered by osteolytic metastatic disease, with diminished bone quality evident at multiple length-scales. The mechanical performance of bone with osteolytic lesions is influenced by a combination of tissue-level and structural changes.

Summary

This review considers the effects of osteolytic metastasis on bone biomechanics demonstrating its negative impact at tissue and structural levels. Future studies need to assess the cumulative impact of cancer treatments on metastatically involved bone quality, and its utility in directing multimodal treatment planning.

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Authors and Affiliations

  1. Orthopaedic Biomechanics Lab, Sunnybrook Research Institute, University of Toronto, Toronto, Canada

    Cari M. Whyne, Dallis Ferguson, Allison Clement, Mohammedayaz Rangrez & Michael Hardisty

  2. Department of Surgery, University of Toronto, Toronto, Canada

    Cari M. Whyne & Michael Hardisty

  3. Biomedical Engineering, University of Toronto, Toronto, Canada

    Cari M. Whyne & Dallis Ferguson

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  1. Cari M. Whyne
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Whyne, C.M., Ferguson, D., Clement, A. et al. Biomechanical Properties of Metastatically Involved Osteolytic Bone. Curr Osteoporos Rep 18, 705–715 (2020). https://doi.org/10.1007/s11914-020-00633-z

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