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Bone Quality in Chronic Kidney Disease: Definitions and Diagnostics

  • Kidney and Bone (S Moe and I Salusky, Section Editors)
  • Published:
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Abstract

Purpose of Review

In this paper, we review the epidemiology, diagnosis, and pathogenesis of fractures and renal osteodystrophy.

Recent Findings

The role of bone quality in the pathogenesis of fracture susceptibility in chronic kidney disease (CKD) is beginning to be elucidated. Bone quality refers to bone material properties, such as cortical and trabecular microarchitecture, mineralization, turnover, microdamage, and collagen content and structure. Recent data has added to our understanding of the effects of CKD on alterations to bone quality, emerging data on the role of abnormal collagen structure on bone strength, the potential of non-invasive methods to inform our knowledge of bone quality, and how we can use these methods to inform strategies that protect against bone loss and fractures. However, more prospective data is required.

Summary

CKD is associated with abnormal bone quality and strength which results in high fracture incidence.

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Authors and Affiliations

  1. Indiana University School of Medicine, Indianapolis, IN, USA

    Erin M. B. McNerny & Thomas L. Nickolas

  2. Division of Nephrology, Department of Medicine, Columbia University Medical Center, 622 West 168th Street, PH4-124, New York, NY, 10032, USA

    Erin M. B. McNerny & Thomas L. Nickolas

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Correspondence to Thomas L. Nickolas.

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McNerny, E.M.B., Nickolas, T.L. Bone Quality in Chronic Kidney Disease: Definitions and Diagnostics. Curr Osteoporos Rep 15, 207–213 (2017). https://doi.org/10.1007/s11914-017-0366-z

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