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Renal Osteodystrophy or Kidney-Induced Osteoporosis?

  • Kidney and Bone (S Moe and I Salusky, Section Editors)
  • Published:
Current Osteoporosis Reports Aims and scope Submit manuscript

Abstract

Purpose of Review

Chronic kidney disease (CKD) affects nearly 10% of the population. The incidence of fractures in population studies demonstrate an increase with worsening stages of kidney disease suggesting specific CKD related causes of fracture.

Recent Findings

The increase in fractures with CKD most likely represents disordered bone quality due to the abnormal bone remodeling from renal osteodystrophy. There is also an increase in fractures with age in patients with CKD, suggesting that patients with CKD also have many fracture risk factors common to patients without known CKD. Osteoporosis is defined by the National Institutes of Health as “A skeletal disorder characterized by compromised bone strength predisposing to an increased risk of fracture. Bone strength reflects the integration of two main features: bone quantity and bone quality.”

Summary

Thus, CKD-related fractures can be considered a type of osteoporosis—where the bone quality is additionally impaired above that of age/hormonal-related osteoporosis. Perhaps using the term CKD-induced osteoporosis, similar to steroid-induced osteoporosis, will allow patients with CKD to be studied in trials investigating therapeutic agents. In this series, we will examine how CKD-induced osteoporosis may be diagnosed and treated.

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Acknowledgements

The authors wish to thank Dr. Naylor and the other authors of the original work [29•] for the adaptation of their original work in the construction of Fig. 1. The author is funded by the Veterans Administration and the National Institute of Health DK11087 and DK100306.

Thank you to Isidro Salusky for reviewing this paper.

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Authors and Affiliations

  1. Division of Nephrology, Indiana University School of Medicine, 950 W. Walnut Street, R2-202, Indianapolis, IN, 46202, USA

    Sharon M. Moe

  2. Department of Medicine, Roudebush Veterans Affairs Medical Center, Indianapolis, IN, USA

    Sharon M. Moe

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Correspondence to Sharon M. Moe.

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Conflict of Interest

Sharon Moe reports other from Sanofi, grants from Chugai, other from Lilly, outside the submitted work. The author reports no disclosures relevant to the current article.

Human and Animal Rights and Informed Consent

This article does not contain any studies with human or animal subjects performed by any of the authors.

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This article is part of the Topical Collection on Kidney and Bone

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Moe, S.M. Renal Osteodystrophy or Kidney-Induced Osteoporosis?. Curr Osteoporos Rep 15, 194–197 (2017). https://doi.org/10.1007/s11914-017-0364-1

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  • DOI: https://doi.org/10.1007/s11914-017-0364-1

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