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DNA Repair Mechanisms and Therapeutic Targets in Glioma

  • Neuro-oncology (KS Nevel, Section Editor)
  • Published:
Current Oncology Reports Aims and scope Submit manuscript

Abstract

Purpose of Review

This review discusses current and investigative strategies for targeting DNA repair in the management of glioma.

Recent Findings

Recent strategies in glioma treatment rely on the production of overwhelming DNA damage and inhibition of repair mechanisms, resulting in lethal cytotoxicity. Many strategies are effective in preclinical glioma models while clinical feasibility remains under investigation. The presence of glioma biomarkers, including IDH mutation and/or MGMT promoter methylation, may confer particular susceptibility to DNA damage and inhibition of repair. These biomarkers have been adopted as eligibility criteria in the design of multiple ongoing clinical trials.

Summary

Targeting DNA repair mechanisms with novel agents or therapeutic combinations is a promising approach to the treatment of glioma. Further investigations are underway to optimize this approach in the clinical setting.

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  1. Department of Neurology, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY, 10065, USA

    Kevin B. Elmore & Lauren R. Schaff

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  1. Kevin B. Elmore
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Correspondence to Lauren R. Schaff.

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Kevin B. Elmore declares that he has no conflict of interest. Lauren R. Schaff has received compensation from Debiopharm for service as a consultant.

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Elmore, K.B., Schaff, L.R. DNA Repair Mechanisms and Therapeutic Targets in Glioma. Curr Oncol Rep 23, 87 (2021). https://doi.org/10.1007/s11912-021-01077-z

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