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Role of Cerebral Microbleeds for Intracerebral Haemorrhage and Dementia

  • Stroke (H.C. Diener, Section Editor)
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Abstract

Purpose of Review

Cerebral microbleeds (CMB)—small round or ovoid lesions detected in hyposignal on blood-sensitive MRI sequences—are promising radiological biomarkers of cerebral small vessel disease. Their relations with ischaemic or haemorragic stroke and their potential contribution to dementia have been extensively addressed. This article reviews recent research on the clinical significance of CMB that remains to be determined.

Recent Findings

The presence, burden and location of CMB allow to obtain a more accurate estimate of intracerebral haemorrhage and ischaemic stroke risk. Most studies evaluating the association between CMB and dementia are hampered by methodological limitations and show conflicting results.

Summary

CMB mainly reflect the severity of the underlying small vessel disease and should not be interpreted independently of the others neuroimaging biomarkers or the clinical setting. Future large prospective longitudinal studies and randomized controlled trials in various settings are required to determine whether specific therapies are beneficial in case of incidental findings.

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Authors and Affiliations

  1. Department of Neurology, Strasbourg University Hospital, Strasbourg, France

    Solene Moulin

  2. Inserm U1171, Degenerative and Vascular Cognitive Disorders, CHU Lille, Department of Neurology, University of Lille, Lille, France

    Charlotte Cordonnier

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  1. Solene Moulin
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Moulin, S., Cordonnier, C. Role of Cerebral Microbleeds for Intracerebral Haemorrhage and Dementia. Curr Neurol Neurosci Rep 19, 51 (2019). https://doi.org/10.1007/s11910-019-0969-0

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