Abstract
One large group of hereditary myopathies characterized by recurrent myoglobinuria, almost invariably triggered by exercise, comprises metabolic disorders of two main fuels, glycogen and long-chain fatty acids, or mitochondrial diseases of the respiratory chain. Differential diagnosis is required to distinguish the three conditions, although all cause a crisis of muscle energy. Muscle biopsy may be useful when performed well after the episode of rhabdomyolysis. Molecular genetics is increasingly the diagnostic test of choice to discover the underlying genetic basis.
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Emanuele Barca, Valentina Emmanuele, and Salvatore DiMauro declare that they have no conflict of interest.
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Barca, E., Emmanuele, V. & DiMauro, S.(. Metabolic Myoglobinuria. Curr Neurol Neurosci Rep 15, 69 (2015). https://doi.org/10.1007/s11910-015-0590-9
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DOI: https://doi.org/10.1007/s11910-015-0590-9