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Molecular Biology of Pediatric Brain Tumors and Impact on Novel Therapies

  • Neuro-Oncology (LE Abrey, Section Editor)
  • Published:
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Abstract

Brain tumors are the leading cause of cancer-related death in children. For the past several decades, therapeutic strategies have centered on cytotoxic chemotherapy and radiation therapy due, in part, to limited understanding of genetic events that underlie tumor initiation and maintenance. Significant improvement in high-throughput genomic methods, such as next-generation sequencing, methylation array, and copy number array, in recent years has propelled the knowledge base from which novel therapies are derived. Translation of recent genomic findings into more effective therapies remains the most formidable challenge in improving the outcome for children with brain tumors.

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Lindsey M. Hoffman, Ralph Salloum, and Maryam Fouladi declare that they have no conflict of interest.

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  1. Cancer and Blood Diseases Institute, Cincinnati Children’s Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, OH, USA

    Lindsey M. Hoffman, Ralph Salloum & Maryam Fouladi

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  1. Lindsey M. Hoffman
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Hoffman, L.M., Salloum, R. & Fouladi, M. Molecular Biology of Pediatric Brain Tumors and Impact on Novel Therapies. Curr Neurol Neurosci Rep 15, 10 (2015). https://doi.org/10.1007/s11910-015-0532-6

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