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Anti-Inflammatory Effects of Melatonin in Obesity and Hypertension

  • Hypertension and Obesity (E Reisin, Section Editor)
  • Published:
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Abstract

Purpose of Review

Here, we review the known relations between hypertension and obesity to inflammation and postulate the endogenous protective effect of melatonin and its potential as a therapeutic agent. We will describe the multiple effects of melatonin on blood pressure, adiposity, body weight, and focus on mitochondrial-related anti-inflammatory and antioxidant protective effects.

Recent Findings

Hypertension and obesity are usually associated with systemic and tissular inflammation. The progressive affection of target-organs involves multiple mediators of inflammation, most of them redundant, which make anti-inflammatory strategies ineffective. Melatonin reduces blood pressure, body weight, and inflammation. The mechanisms of action of this ancient molecule of protection involve multiple levels of action, from subcellular to intercellular. Mitochondria is a key inflammatory element in vascular and adipose tissue and a potential pharmacological target. Melatonin protects against mitochondrial dysfunction.

Summary

Melatonin reduces blood pressure and adipose tissue dysfunction by multiple anti-inflammatory/antioxidant actions and provides potent protection against mitochondria-mediated injury in hypertension and obesity. This inexpensive and multitarget molecule has great therapeutic potential against both epidemic diseases.

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Authors and Affiliations

  1. Instituto de Medicina y Biología Experimental de Cuyo (IMBECU), Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Mendoza, Argentina

    Natalia Jorgelina Prado, Walter Manucha & Emiliano Raúl Diez

  2. Pediatric Department Nephrology Division, Miller School of Medicine, University of Miami, Florida, USA

    León Ferder

  3. Área de Farmacología, Facultad de Ciencias Médicas, Universidad Nacional de Cuyo, Mendoza, Argentina

    Walter Manucha

  4. Instituto de Fisiología, Facultad de Ciencias Médicas, Universidad Nacional de Cuyo, Centro Universitario, CP 5500, Mendoza, Argentina

    Emiliano Raúl Diez

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Prado, N.J., Ferder, L., Manucha, W. et al. Anti-Inflammatory Effects of Melatonin in Obesity and Hypertension. Curr Hypertens Rep 20, 45 (2018). https://doi.org/10.1007/s11906-018-0842-6

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