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Cytoskeletal Regulation of TRPC Channels in the Cardiorenal System

  • Mediators, Mechanisms, and Pathways in Tissue Injury (B Rothermel, Section Editor)
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Abstract

Transient receptor potential canonical (TRPC) channels have been implicated in several aspects of cardiorenal physiology including regulation of blood pressure, vasoreactivity, vascular remodeling, and glomerular filtration. Gain and loss of function studies also support the role of TRPC channels in adverse remodeling associated with cardiac hypertrophy and heart failure. This review discusses TRP channels in the cardiovascular and glomerular filtration systems and their role in disease pathogenesis. We describe the regulation of gating of TRPC channels in the cardiorenal system as well as the influence on activation of these channels by the underlying cytoskeleton and scaffolding proteins. We then focus on the role of TRP channels in the pathogenesis of adverse cardiac remodeling and as potential therapeutic targets in the treatment of heart failure.

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Acknowledgments

This work was supported by Award Number R01HL093470 (PBR) from the National Heart, Lung, and Blood Institute. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Heart, Lung, and Blood Institute or the National Institutes of Health. Additional support includes a MDA research award (PBR), a HHMI Physician Scientist Early Career Award (JAS), American Heart Association Beginning Grant-in-Aid (JAS), and a Mandel Foundation Award (PBR, JAS).

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Authors and Affiliations

  1. Department of Medicine and Ion Channel Research Unit, Duke University Medical Center, Box 103030, Durham, NC, 27710, USA

    Jonathan A. Stiber, Youlan Tang, TianYu Li & Paul B. Rosenberg

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  1. Jonathan A. Stiber
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  2. Youlan Tang
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  4. Paul B. Rosenberg
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Correspondence to Paul B. Rosenberg.

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Stiber, J.A., Tang, Y., Li, T. et al. Cytoskeletal Regulation of TRPC Channels in the Cardiorenal System. Curr Hypertens Rep 14, 492–497 (2012). https://doi.org/10.1007/s11906-012-0313-4

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