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Adipose Tissue as Regulator of Vascular Tone

  • SECONDARY HYPERTENSION: ADRENAL AND NERVOUS SYSTEM MECHANISMS (S OPARIL AND KH BERECEK, SECTION EDITORS)
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Abstract

Adipokines secreted by visceral, subcutaneous, and perivascular adipocytes are involved in the regulation of vascular tone by acting as circulatory hormones (leptin, adiponectin, omentin, visfatin, angiotensin II, resistin, tumor necrosis factor-α, interleukin-6, apelin) and/or via local paracrine factors (perivascular adipocyte-derived relaxing and contractile factors). Vascular tone regulation by adipokines is compromised in obesitas and obesity-related disorders. Hypoxia created in growing adipose tissue dysregulates synthesis of vasoactive adipokines in favor of harmful proinflammatory adipokines, while the levels of the cardioprotective adipokines adiponectin and omentin decrease. Considering the potential of the role of adipokines in obesity-related vascular diseases, strategies to counter these diseases by targeting the adipokines are discussed.

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Acknowledgment

This work was supported by a grant of Geconcerteerde Onderzoeksactie (GOA) of Ghent University.

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  1. Department of Pharmacology, Ghent University, De Pintelaan 185–Blok B (2nd Floor), 9000, Ghent, Belgium

    Charlotte Boydens, Nele Maenhaut, Bart Pauwels, Kelly Decaluwé & Johan Van de Voorde

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  1. Charlotte Boydens
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Boydens, C., Maenhaut, N., Pauwels, B. et al. Adipose Tissue as Regulator of Vascular Tone. Curr Hypertens Rep 14, 270–278 (2012). https://doi.org/10.1007/s11906-012-0259-6

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  • DOI: https://doi.org/10.1007/s11906-012-0259-6

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