Current Hepatology Reports

, Volume 17, Issue 2, pp 111–120 | Cite as

Strategies for the Elimination of Hepatitis C Virus Infection as a Public Health Threat in the United States

  • Charitha Gowda
  • Vincent Lo ReIII
Hepatitis C (A Aronsohn and H Vargas, Section Editors)
Part of the following topical collections:
  1. Topical Collection on Hepatitis C


Purpose of Review

Direct-acting antiviral regimens for chronic hepatitis C virus (HCV) infection became available in 2014, and these highly curative therapies have the potential to reduce HCV-associated morbidity and mortality, decrease HCV transmission, and eliminate HCV infection as a public health problem. This review summarizes the recommendations by the National Academies of Sciences, Engineering, and Medicine for a US strategy for HCV elimination.

Recent Findings

To achieve proposed targets of reducing HCV incidence by 90% and decreasing HCV-related mortality by 60% by 2030, there is a critical need to improve HCV diagnosis and linkage to care, reduce HCV-related disease by antiviral treatment scale-up, reduce HCV incidence, and strengthen HCV surveillance to determine achievement of HCV elimination targets over time.


While HCV elimination is feasible, success of this national effort will require ongoing collaboration and critical resource investment by key stakeholders, including medical and public health communities, legislators, community organizers, and patient advocates.


Hepatitis C Elimination US public health threats 


Compliance with Ethical Standards

Conflict of Interest

Charitha Gowda declares no conflicts of interest.

Vincent Lo Re reports grants from AstraZeneca and reports having served on the committee convened by the National Academies of Sciences, Engineering, and Medicine to outline a national strategy for HCV elimination, outside the submitted work.

Human and Animal Rights and Informed Consent

This article does not contain any studies with human or animal subjects performed by any of the authors.


Papers of particular interest, published recently, have been highlighted as: • Of importance •• Of major importance

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Authors and Affiliations

  1. 1.Department of PediatricsThe Ohio State College of MedicineColumbusUSA
  2. 2.Division of Infectious Diseases, Department of Medicine, Perelman School of MedicineUniversity of PennsylvaniaPhiladelphiaUSA
  3. 3.Department of Biostatistics, Epidemiology, and Informatics, Center for Clinical Epidemiology and Biostatistics, Center for Pharmacoepidemiology Research and Training, Perelman School of MedicineUniversity of PennsylvaniaPhiladelphiaUSA
  4. 4.Center for AIDS Research, Perelman School of MedicineUniversity of PennsylvaniaPhiladelphiaUSA

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