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Novel Immunotherapies for T Cell Lymphoma and Leukemia

  • CART and Immunotherapy (M Ruella, Section Editor)
  • Published:
Current Hematologic Malignancy Reports Aims and scope Submit manuscript

Abstract

Purpose of Review

Novel immunotherapies such as checkpoint inhibitors, bispecific antibodies, and chimeric antigen receptor T cells are leading to promising responses when treating solid tumors and hematological malignancies. T cell neoplasms include leukemia and lymphomas that are derived from T cells and overall are characterized by poor clinical outcomes. This review describes the rational and preliminary results of immunotherapy for patients with T cell lymphoma and leukemia.

Recent Findings

For T cell neoplasms, despite significant research effort, only few agents, such as monoclonal antibodies and allogeneic stem cell transplantation, showed some clinical activity. One of the major hurdles to targeting T cell neoplasms is that activation or elimination of T cells, either normal or neoplastic, can cause significant toxicity. A need to develop novel safe and effective immunotherapies for T cell neoplasms exists.

Summary

In this review, we will discuss the rationale for immunotherapy of T cell leukemia and lymphoma and present the most recent therapeutic approaches.

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Funding

This research was funded in part through the NIH/NCI Cancer Center Support Grant P30 CA008748, the Gabrielle’s Angel Foundation grant (PI: M.R.), the Parker Institute for Cancer Immunotherapy (PI: M.R.), the ASH Scholar Award (PI: M.R.), and the NCI CDA (K99 CA212302-01A1, PI: M.R.).

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Authors and Affiliations

  1. Lymphoma Service, Memorial Sloan Kettering Cancer Center, New York, NY, USA

    Paola Ghione, Alison J. Moskowitz, Nadia E. K. De Paola & Steven M. Horwitz

  2. Center for Cellular Immunotherapies, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA

    Marco Ruella

  3. Division of Hematology and Oncology, University of Pennsylvania, Philadelphia, PA, USA

    Marco Ruella

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  1. Paola Ghione
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  2. Alison J. Moskowitz
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  3. Nadia E. K. De Paola
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  5. Marco Ruella
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Correspondence to Marco Ruella.

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Conflict of Interest

Steven M. Horwitz reports grants and personal fees from ADC Therapeutics, grants and personal fees from Aileron, grants and personal fees from Seattle Genetics, grants and personal fees from Takeda, grants and personal fees from Kyowa Hakka Kirin, grants and personal fees from Verastem, personal fees from Portola, personal fees from Corvus, grants from Celgene, grants from Spectrum, and grants from Forty-Seven outside the submitted work. Alison J. Moskowitz reports grants from Merck, grants from BMS, grants from Incyte, grants and personal fees from Seattle Genetics, personal fees from Bristol-Meyers Squibb, personal fees from Cell Medica, and personal fees from Kyowa Hakko Kirin Pharma outside the submitted work. Paola Ghione, Nadia E.K. De Paola, and Marco Ruella declare that they have no conflict of interest. Marco Ruella reports grants from Novartis and Tmunity, and intellectual property in CART-related patents.

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Ghione, P., Moskowitz, A.J., De Paola, N.E.K. et al. Novel Immunotherapies for T Cell Lymphoma and Leukemia. Curr Hematol Malig Rep 13, 494–506 (2018). https://doi.org/10.1007/s11899-018-0480-8

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