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Using Genetics to Identify Hereditary Colorectal Polyposis and Cancer Syndromes in Your Patient

  • Large Intestine (B Cash, Section Editor)
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Abstract

The majority of patients with colorectal polyps and cancer do not have a Mendelian cause of the disease. Age, lifestyle, and environmental factors interact with complex genetic traits to contribute to the etiology. However, approximately 5–10 % of patients with colorectal cancer (CRC) and more than 40 % of patients meeting specific clinical features of the hereditary polyposis syndromes have a discoverable, actionable genetic cause which will significantly alter their medical management.

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Conflict of Interest

Carole Macaron, and Carol A. Burke declare that they have no conflict of interest. Brandie Heald is on the Speakers Bureau for Myriad Genetics Laboratory.

Human and Animal Rights and Informed Consent

This article contains studies with human subjects performed by the authors.

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Authors and Affiliations

  1. Section of Gastroenterology, Department of Veterans Affairs, Louis Stokes Cleveland Medical Center, Cleveland, 44106, OH, USA

    Carole Macaron

  2. Genomic Medicine Institute, Cleveland Clinic, Cleveland, OH, USA

    Brandie Heald

  3. Department of Gastroenterology and Hepatology, Cleveland Clinic, Cleveland, OH, USA

    Brandie Heald & Carol A. Burke

  4. Department of Gastroenterology and Hepatology, Cleveland Clinic, Desk A 30, 9500 Euclid Ave, Cleveland, OH, 44195, USA

    Carol A. Burke

Authors
  1. Carole Macaron
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  2. Brandie Heald
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  3. Carol A. Burke
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Corresponding author

Correspondence to Carol A. Burke.

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This article is part of the Topical Collection on Large Intestine

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Macaron, C., Heald, B. & Burke, C.A. Using Genetics to Identify Hereditary Colorectal Polyposis and Cancer Syndromes in Your Patient. Curr Gastroenterol Rep 17, 39 (2015). https://doi.org/10.1007/s11894-015-0463-z

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  • DOI: https://doi.org/10.1007/s11894-015-0463-z

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