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Adult-to-adult living donor liver transplantation

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Abstract

Adult-to-adult living donor liver transplantation has become the subject of a great deal of attention over the last few years. Until the use of the donor right lobe was introduced and demonstrated to be relatively safe, it was not possible to offer this alternative to conventional transplantation to most adults. Recent clinical work has focused on the results of these procedures in both donors and recipients, perfecting surgical techniques for right-lobe transplantation, streamlining donor evaluation protocols, and containing costs. This overview summarizes many of the recent publications and presentations in the field of adult-to-adult living donor liver transplantation.

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References and Recommended Reading

  1. Millis J, Cronin D, Brady L, et al.: Primary living-donor liver transplantation at the University of Chicago. Ann Surg 2000, 232:104–111. The authors summarize their extensive experience as a transplant team with pediatric living donor liver transplantation and describe their surgical techniques.

    Article  PubMed  CAS  Google Scholar 

  2. Whitington P: Living donor liver transplantation: ethical considerations. J Hepatol, 1996:625–627.

  3. Marcos A, Fisher R, Ham J, et al.: Right lobe living donor liver transplantation. Transplantation 1999, 68:798–803. Adetailed description of the surgical techniques used for right-lobe living donor transplantation.

    Article  PubMed  CAS  Google Scholar 

  4. Inomata Y, Uemoto S, Asonuma K, et al.: Right lobe graft in living donor liver transplantation. Transplantation 2000, 69:259–264.

    Article  Google Scholar 

  5. Fan S, Lo C, Liu C, et al.: Safety of donors in live donor liver transplantation using right lobe grafts. Arch Surg 2000, 135:336–340.

    Article  PubMed  CAS  Google Scholar 

  6. Cheng Y, Huang T, Chen C, et al.: Variations of the left and middle hepatic veins: application in living related hepatic transplantation. J Clin Ultrasound 1996, 24:11–16.

    Article  PubMed  CAS  Google Scholar 

  7. Takayama T, Makuuchi M, Kubota K, et al.: Living-related transplantation of left liver plus caudate lobe. J Am Coll Surg 2000, 190:635–638.

    Article  PubMed  CAS  Google Scholar 

  8. Inomata Y, Tanaka K, Uemoto S, et al.: Living donor liver transplantation: an 8-year experience with 379 consecutive cases. Transplant Proc 1999, 31:381.

    Article  PubMed  CAS  Google Scholar 

  9. Rogiers X, Malago M, Nollkemper D, et al.: The Hamburg liver transplant program. Clin Transpl 1997, 183–190.

  10. Tojimbara T, Fuchinoue S, Nakajima I, et al.: Analysis of postoperative liver function of donors in living-related liver transplantation: comparison of the type of donor hepatectomy. Transplantation 1998, 66:1035–1039.

    Article  PubMed  CAS  Google Scholar 

  11. Renz J, Reichert P, Emond J: Hepatic arterial anatomy as applied to living-donor and split liver transplantation. Liver Transpl 2000, 6:367–369.

    Article  PubMed  CAS  Google Scholar 

  12. Ikegami T, Kawasaki S, Matsunami H, et al.: Should all hepatic arterial branches be reconstructed in living-related liver transplantation? Surgery 1996, 199:431–436.

    Article  Google Scholar 

  13. Mori K, Nagata I, Yamagata S, et al.: The introduction of microvascular surgery to hepatic artery reconstruction in living donor liver transplantation: its surgical advantages compared with conventional procedures. Transplantation 1992, 54:263–267.

    Article  PubMed  CAS  Google Scholar 

  14. Dondero F, Durand F, Ettorre G, et al.: Morbidity of living related liver harvesting is not influenced by the extent of resection [abstract]. Hepatology 2000, 32:214A.

    Google Scholar 

  15. Lo C, Fan S, Liu C, et al.: Minimum graft size for successful living donor liver transplantation. Transplantation 1999, 68:1112–1116. A comprehensive analysis of the effect of graft mass on outcome following living donor transplantation.

    Article  PubMed  CAS  Google Scholar 

  16. Marcos A, Fisher R, Ham J, et al.: Liver regeneration and function in donor and recipient after adult to adult living donor liver transplantation. Transplantation 2000, 69:1375–1379. This article describes the time frame over which the liver regenerates in both donors and recipients following right-lobe resection or transplantation. It also addresses regeneration in terms of the size of the graft or remnant and the influence of steatosis on the process.

    Article  PubMed  CAS  Google Scholar 

  17. Ben-Haim M, Emre S, Facciuto M, et al.: Critical graft size in adult to adult living donor liver transplantation: the impact of the recipient’s disease. Transplantation 2000, 69(suppl):S290.

    Google Scholar 

  18. Marcos A, Ham J, Fisher R, et al.: Single center analysis of the first forty living donor transplants using the right lobe. Liver Transpl 2000, 6:296–301.

    Article  PubMed  CAS  Google Scholar 

  19. Egawa H, Inomata Y, Uemoto S, et al.: Surgical innovation in 70 living donor liver transplants utilizing the right lobe. Transplantation 2000, 69(suppl):S290.

    Google Scholar 

  20. Bak T, Wachs M, Trotter J, et al.: Adult donors of right hepatic lobes for living donor liver transplantation: results of first 16 patients. Transplantation 2000, 69(suppl):S175.

    Google Scholar 

  21. Pomposelli J, Pomfret E, Kamel I, et al.: Living donor adult liver transplantation (LDALT): donor evaluation, outcome, and resource ultilization. Transplantation 2000, 69(suppl):S291.

    Google Scholar 

  22. Grewal H, Shokouh-Amiri M, Vera S, et al.: Adult living donor liver transplantation without veno-venous bypass, caval clamping or porta-caval decompression and with duct-to-duct biliary reconstruction. Transplantation 2000, 69(suppl):S177.

    Article  Google Scholar 

  23. Malago M, Testa G, Valentin-Gamazo C, et al.: Living donor right hepatectomy: donor selection, risks, and influence on recipient outcome. Transplantation 2000, 69(suppl):S172.

    Article  Google Scholar 

  24. Colter S, Patil R, Banaad G: Living donor liver transplantation: a survey of perceptions and preferences [abstract]. Hepatology 2000, 32:313A.

    Google Scholar 

  25. Renz J, Diaz G, Roberts J, et al.: Donor health assessment following living-donor liver transplantation. Transplantation 2000, 69(suppl):S291.

    Google Scholar 

  26. Marcos A, Fisher R, Ham J, et al.: Selection and outcome of living donors for adult to adult right lobe transplantation. Transplantation 2000, 69:2410–2415. A comprehensive right-lobe donor evaluation protocol is included along with the rationale for the various studies. Exclusion criteria are also addressed.

    Article  PubMed  CAS  Google Scholar 

  27. Flamm S, Alonso E, Blei A, et al.: The role of liver biopsy in the evaluation of living donors. Transplantation 2000, 69(suppl):S174.

    Google Scholar 

  28. Kim-Schluger L, Abittan C, O’Rourke M, et al.: Evaluation of potential adult-to-adult living donors: routine biopsies are not indicated [abstract]. Hepatology 2000, 32:251A.

    Article  Google Scholar 

  29. Marcos A, Ham J, Fisher R, et al.: Surgical management of anatomical variations of the right lobe in living donor liver transplantation. Ann Surg 2000, 231:824–831. This paper summarizes the most commonly encountered anatomic variations of the right hepatic lobe and describes their successful management.

    Article  PubMed  CAS  Google Scholar 

  30. Morgan G, Lee V, Krinsky G, et al.: Duct to duct biliary anastomosis with t-tube drainage in adult right lobe living donor liver transplantation without bile leaks [abstract]. Hepatology 2000, 34:214A.

    Google Scholar 

  31. Morgan G, Lee V, Rofsky N, et al.: MRI as the sole pre-operative imaging modality for living related liver transplant donor evaluation. Transplantation 2000, 69(suppl):S179.

    Google Scholar 

  32. Wachs M, Bak T, Everson G, et al.: Adult living donor liver transplant: results and anatomical considerations [abstract]. Hepatology 2000, 32:213A.

    Google Scholar 

  33. Department of Health and Human Services: 1999 Annual Report: The U.S. Scientific Registry of Transplant Recipients and the Organ Procurement and Transplantation Network. Washington, DC: DHHS; 1999:151.

    Google Scholar 

  34. Egawa H, Inomata Y, Uemoto S: Hepatic vein reconstruction in 152 living-related donor liver transplantation patients. Surgery 1997, 121:250–257.

    Article  PubMed  CAS  Google Scholar 

  35. Marcos A, Olzinski A, Ham J, et al.: The interrelationship between portal and arterial blood after following adult to adult living donor liver transplantation. Transplantation 2000, in press.

  36. Salame E, Schmutz G, Emond J, et al.: Clinico-anatomical and radiological study of the drainage territory of the middle hepatic vein: application on living liver transplantation [abstract]. Hepatology 2000, 34:251A.

    Google Scholar 

  37. Marcos A, Fisher R, Ham J, et al.: Emergency adult to adult living donor transplantation for fulminant hepatic failure. Transplantation 2000, 69:2202–2205.

    Article  PubMed  CAS  Google Scholar 

  38. Lo C, Fan S, Liu C, et al.: Favorable outcome with clinical application of living donor liver transplantation to patients with fulminant hepatic failure. Transplantation 2000, 69(suppl):S173.

    Google Scholar 

  39. Selby R, Korula J, Mateo R, et al.: Comparison of the pre-transplant costs and medical acuity between adult cadaveric versus live-donor liver transplant recipients [abstract]. Hepatology 2000, 32:252A.

    Google Scholar 

  40. Ham J, Marcos A, Fisher R, et al.: Is living donor liver transplantation cost effective? Transplantation 2000, 69(suppl):S175.

    Google Scholar 

  41. Trotter J, Wachs M, Nold K, et al.: A comparison of charges for organ acquisition: adult cadaveric vs. adult living donor liver transplantation. Transplantation 2000, 69(suppl):S175.

    Google Scholar 

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Olzinski, O.T., Marcos, A. Adult-to-adult living donor liver transplantation. Curr Gastroenterol Rep 3, 65–70 (2001). https://doi.org/10.1007/s11894-001-0043-2

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  • DOI: https://doi.org/10.1007/s11894-001-0043-2

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