Abstract
Living donor liver transplantation (LDLT) has evolved over the last 20 years as an alternative to deceased donor transplant to overcome the shortage of organs. Living organ donation is the only procedure where the person undergoes a surgery for no underlying medical condition with no potential for medical benefit. The potential for serious morbidity and mortality of the healthy donor has been the major limiting factor in the development of this procedure. Its benefits, however, are more obvious in parts of the world where deceased donation is not existent. Although it is technically demanding and labor intensive, LDLT has continued to evolve with increased donor safety and recipient outcomes.
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References
Health Resources and Service Administration. Organ Procurement and Transplantation Network. http://www.optn.org.
Raia S, Nery JR, Mies S, et al. Liver transplantation from live donors. Lancet. 1989;2:497.
Strong RW, Lynch SV, Ong TH, Matsunami H, Koido Y, Balderson GA, et al. Successful liver transplantation from a living donor to her son. N Engl J Med. 1990;322:1505–7.
Hashikura Y, Makuuchi M, Kawasaki S, Matsunami H, Ikegami T, Nakazawa Y, et al. Successful living-related partial liver transplantation to an adult patient. Lancet. 1994;343:1233–4.
Lo CM, Fan ST, Liu CL, Lo RJ, Lau GK, Wei WI, et al. Extending the limit on the size of adult recipient in living donor liver transplantation using extended right lobe graft. Transplantation. 1997;63:1524–8.
Wachs ME, Bak TE, Karrer FM, Everson GT, Shrestha R, Trouillot TE, et al. Adult living donor liver transplantation using a right hepatic lobe. Transplantation. 1998;66:1313–6.
Tuttle-Newhall JE, Collins BH, Desai DM, Kuo PC, Heneghan ME, et al. The current status of living donor liver transplantation. Curr Prob Surg. 2005;42:144–83.
Rudow DL, Brown RS. Jr. Evaluation of living liver donors. Prog Transplant. 2003;13:110–6.
Rinella ME, Alonso E, Rao S, Whitington P, Fryer J, Abecassis M, et al. Body mass index as a predictor of hepatic steatosis in living liver donors. Liver Transpl. 2001;7:409–14.
Trotter JF. Selection of donors and recipients for living donor liver transplantation. Liver Transpl. 2000;6:S52–8.
Chen YS, Cheng YF, De Villa VH, Wang CC, Lin CC, Huang TL, et al. Evaluation of living liver donors. Transplantation. 2003;75:S16–9.
Alonso-Torres A, Fernandez-Cuadrado J, Pinilla I, Parron M, Vicente E de, Lopez-Santamaria M, et al. Multidetector CT in the evaluation of potential living donors for liver transplantation. Radiographics. 2005;25:1017–30.
Valentin-Gamazo C, Malago M, Karliova M, Lutz JT, Frilling A, Nadalin S, et al. Experience after the evaluation of 700 potential donors for living donor liver transplantation in a single center. Liver Transpl. 2004;10:1087–96.
Muzaale AD, Dagher NN, Montgomery RA, Taranto SE, Mcbride MA, Segev DL, et al. Estimates of early death, acute liver failure, and long-term mortality among live liver donors. Gastroenterology. 2012;142:273–80.
Nadalin S, Malago M, Valentin-Gamazo C, Testa G, Baba HA, Liu C, et al. Preoperative donor liver biopsy for adult living donor liver transplantation: risks and benefits. Liver Transpl. 2005;11:980–6.
Nakamuta M, Morizono S, Soejima Y, Yoshizumi T, Aishima S, Takasugi S, et al. Short-term intensive treatment for donors with hepatic steatosis in living-donor liver transplantation. Transplantation. 2005;80:608–12.
Jacobs C, Johnson E, Anderson K, Gillingham K, Matas A, et al. Kidney transplants from living donors: how donation affects family dynamics. Adv Ren Replace Ther. 1998;5:89–97.
Schover LR, Streem SB, Boparai N, Duriak K, Novick AC. The psychosocial impact of donating a kidney: long-term follow-up from a urology based center. J Urol. 1997;157:1596–601.
Lee SG, Park KM, Hwang S, Lee YJ, Kim KH, Ahn CS, et al. Adult-to-adult living donor liver transplantation at the Asan Medical Center, Korea. Asian J Surg. 2002;25:277–84.
Ben-Haim M, Emre S, Fishbein T, Sheiner P, Bodian C, Kim-Schluger L, et al. Critical graft size in adult-to-adult living donor liver transplantation: impact of the recipient’s disease. Liver Transpl. 2001;7:948–53.
Taketomi A, Kayashima H, Soejima Y, Yoshizumi T, Uchiyama H, Ikegami T et al. Donor risk in adult-to-adult living donor liver transplantation: impact of left lobe graft. Transplantation. 2009;87:445–50.
Kanoh K, Nomoto K, Shimura T, Shimada M, Sugimachi K, Kuwano H, et al. A comparison of right-lobe and left-lobe graft for living-donor liver transplantation. Hepatogastroenterology. 2002;49:222–4.
Humar A, Kosari K, Sielaff TD, Glessing B, Gomes M, Dietz C, et al. Liver regeneration after adult living donor and deceased donor split-liver transplants. Liver Transpl. 2004;10:374–8.
Middleton PF, Duffield M, Lynch SV, Padbury RT, House T, Stanton P, et al. Living donor liver transplantation—adult donor outcomes: a systematic review. Liver Transpl. 2006;12:24–30.
Trotter JF, Adam R, Lo CM, Kenison J, et al. Documented deaths of hepatic lobe donors for living donor liver transplantation. Liver Transpl. 2006;12:1485–8.
Salvalaggio PR, Baker TB, Koffron AJ, Fryer JP, Clark L, Superina RA, et al. Comparative analysis of live liver donation risk using a comprehensive grading system for severity. Transplantation. 2004;77:1765–7.
Brown RS Jr, Russo MW, Lai M, Shiffman ML, Richardson MC, Everhart JE, et al. A survey of liver transplantation from living adult donors in the United States. N Engl J Med. 2003;348:818–25.
Lo CM. Complications and long-term outcome of living liver donors: a survey of 1508 cases in five Asian Centers. Transplantation. 2003;75:S12–5.
Broering DC, Wilms C, Bok P, Fischer L, Mueller L, Hillert C, et al. Evolution of donor morbidity in living related liver transplantation: a single-center analysis of 165 cases. Ann Surg. 2004;240:1013–26.
Ghobrial RM, Freise CE, Trotter JF, Tong L, Ojo AO, Fair JH, et al. A2ALL Study Group. Donor morbidity after living donation for liver transplantation. Gastroenterology. 2008;135:468–76.
Dindo D, Demartines N, Clavien PA, et al. Classification of surgical complications: a new proposal with evaluation in a cohort of 6336 patients and results of a survey. Ann Surg. 2004;240:205–13.
Yuan Y, Gotoh M. Biliary complications in living liver donors. Surg Today. 2010;40:411–7.
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Gunabushanam, V., Chaudhary, A., Humar, A. (2014). Living Donor Liver Transplantation. In: STEEL, J. (eds) Living Donor Advocacy. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-9143-9_3
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DOI: https://doi.org/10.1007/978-1-4614-9143-9_3
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