Köbberling J, Tillil H: Empirical risk figures for first degree relatives of non-insulin-dependent diabetics. In The Genetics of Diabetes Mellitus. Edited by Köbberling J, Tattersall R. London: Academic Press; 1982:201–209.
McCarthy MI: Growing evidence for diabetes susceptibility genes from genome scan data. Curr Diab Rep 2003, 3:159–167.
Guan W, Pluzhnikov A, Cox NJ, Boehnke M; International Type 2 Diabetes Linkage Analysis Consortium: Meta-analysis of 23 type 2 diabetes linkage studies from the international type 2 diabetes linkage analysis consortium. Hum Hered 2008, 66:35–49.
International HapMap Consortium: A haplotype map of the human genome. Nature 2005, 437:1299–1320.
Frayling TM, Timpson NJ, Weedon MN, et al.: A common variant in the FTO gene is associated with body mass index and predisposes to childhood and adult obesity. Science 2007, 316:889–894.
Altshuler D, Hirschhorn JN, Klannemark M, et al.: The common PPARgamma Pro12Ala polymorphism is associated with decreased risk of type 2 diabetes. Nat Genet 2000, 26:76–80.
Gloyn AL, Weedon MN, Owen KR, et al.: Large scale association studies of variants in genes encoding the pancreatic beta-cell K-ATP channel subunits Kir6.2 (KCNJ11) and SUR1 (ABCC8) confirm that the KCNJ11 E23K variant is associated with increased risk of type 2 Diabetes. Diabetes 2003, 52:568–572.
Sandhu MS, Weedon MN, Fawcett KA, et al.: Common variants in WFS1 confer risk of type 2 diabetes. Nat Genet 2007, 39:951–953.
Winckler W, Weedon MN, Graham RR, et al.: Evaluation of common variants in the six known MODY genes for association with type 2 Diabetes. Diabetes 2007, 56:685–693.
Gudmundsson J, Sulem P, Steinthorsdottir V, et al.: Two variants on chromosome 17 confer prostate cancer risk, and the one in TCF2 protects against type 2 diabetes. Nat Genet 2007, 39:977–983.
Grant SF, Thorleifsson G, Reynisdottir I, et al.: Variant of transcription factor 7-like 2 (TFC7L2) gene confers risk of type 2 diabetes. Nat Genet 2006, 38:320–323.
Diabetes Genetics Initiative of Broad Institute of Harvard and MIT, Lund University, and Novartis Institutes of BioMedical Research: Genome-wide association analysis identifies loci for type 2 diabetes and triglyceride levels. Science 2007, 316:1331–1336.
Scott LJ, Mohlke KL, Bonnycastle LL, et al.: A genome-wide association study of type 2 diabetes in Finns detects multiple susceptibility variants. Science 2007, 316:1341–1345.
Wellcome Trust Case Control Consortium: Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls. Nature 2007, 447:661–678.
Zeggini E, Weedon MN, Lindgren CM, et al.: Replication of genome-wide association signals in U.K. samples reveals risk loci for type 2 diabetes. Science 2007, 316:1336–1341.
Sladek R, Rocheleau G, Rung J, et al.: A genome-wide association study identifies novel risk loci for type 2 diabetes. Nature 2007, 445:828–830.
Salonen JT, Uimari P, Aalto JM, et al.: Type 2 diabetes whole-genome association study in four populations: the DiaGen consortium. Am J Hum Genet 2007, 81:338–345.
Steinthorsdottir V, Thorleifsson G, Reynisdottir I, et al.: A variant in CDKAL1 influences insulin response and risk of type 2 diabetes. Nat Genet 2007, 39:770–775.
Unoki H, Takahashi A, Kawaguchi T, et al.: SNPs in KCNQ1 are associated with susceptibility to type 2 diabetes in East Asian and European populations. Nat Genet 2008, 40:1098–1102.
Zeggini E, Scott LJ, Saxena R, et al.: Meta-analysis of genome-wide association data and large-scale replication identifies additional susceptibility loci for type 2 diabetes. Nat Genet 2008, 40:638–645.
Prokopenko I, Langenberg C, Florez JC, et al.: Variants in the melatonin receptor 1B gene (MTNR1B) influence fasting glucose levels. Nat Genet 2009, 41:77–81.
Lyssenko V, Nagorny CL, Erdos MR, et al.: Common variant in MTNR1B associated with increased risk of type 2 diabetes and impaired early insulin secretion. Nat Genet 2009, 41:82–88.
Bouatia-Naji N, Bonnefond A, Cavalcanti-Proenca C, et al.: A variant near MTNR1B is associated with increased fasting plasma glucose levels and type 2 diabetes risk. Nat Genet 2009, 41:89–94.
Yasuda K, Miyake K, Horikawa Y, et al.: Variants in KCNQ1 are associated with susceptibility to type 2 diabetes mellitus. Nat Genet 2008, 40:1092–1097.
Marchini J, Howie B, Myers S, et al.: A new multipoint method for genome-wide association studies by imputation of genotypes. Nat Genet 2007, 39:906–913.
Fan JB, Chee MS, Gunderson KL: Highly parallel genomic assays. Nat Rev Genet 2006, 7:632–644.
Zeggini E, Rayner W, Morris AP, et al.: HapMap sample size and tagging SNP performance: an evaluation in largescale empirical and simulated data sets. Nat Genet 2005, 37:1320–1322.
McCarroll SA, Huett A, Kuballa P, et al.: Deletion polymorphism upstream of IRGM associated with altered IRGM expression and Crohn’s disease. Nat Genet 2008 Aug 24 (Epub ahead of print).
Frayling TM: Genome-wide association studies provide new insights into type 2 diabetes aetiology. Nat Rev Genet 2007, 8:657–662.
McCarthy MI, Abecasis GR, Cardon LR, et al.: Genome wide association studies for complex traits: consensus, uncertainty and challenges. Nat Rev Genet 2008, 9:356–369.
Lohmueller KE, Pearce CL, Pike M, et al.: Meta-analysis of genetic association studies supports a contribution of common variants to susceptibility to common disease. Nat Genet 2003, 33:177–182.
Dabelea D, Pettitt DJ: Intrauterine diabetic environment confers risks for type 2 diabetes mellitus and obesity in the offspring, in addition to genetic susceptibility. J Pediatr Endocrinol Metab 2001, 14:1085–1091.
McCarthy MI: Casting a wider net for diabetes-susceptibility genes. Nat Genet 2008, 40:1039–1040.
McCarroll SA, Kuruvilla FG, Korn JM, et al.: Integrated detection and population-genetic analysis of SNPs and copy number variation. Nat Genet 2008, 40:1166–1174.
Hill WG, Goddard ME, Visscher PM: Data and theory point to mainly additive genetic variance for complex traits. PLoS Genet 2008, 4:e1000008.
Smyth DJ, Cooper JD, Howson JM, et al.: PTPN22 Trp620 explains the association of chromosome 1p13 with type 1 diabetes and shows a statistical interaction with HLA class II genotypes. Diabetes 2008, 57:1730–1737.
Grarup N, Rose CS, Andersson EA, et al.: Studies of association of variants near the HHEX, CDKN2A/B, and IGF2BP2 genes with type 2 diabetes and impaired insulin release in 10,705 Danish subjects. Diabetes 2007, 56:3105–3111.
Pascoe L, Tura A, Patel SK, et al.: Common variants of the novel type 2 diabetes genes, CDKAL1 and HHEX/IDE, are associated with decreased pancreatic beta-cell function. Diabetes 2007, 56:3101–3104.
Staiger H, Machicao F, Stefan N, et al.: Polymorphisms within novel risk loci for type 2 diabetes determine beta-cell function. PLoS One 2007, 9:e832.
Staiger H, Stancáková A, Zilinskaite J, et al.: A candidate type 2 diabetes polymorphism near the HHEX locus affects acute glucose-stimulated insulin release in European populations. Diabetes 2008, 57:514–517.
Freathy RM, Timpson NJ, Lawlor DA, et al.: Common variation in the FTO gene alters diabetes-related metabolic traits to the extent expected, given its effect on BMI. Diabetes 2008, 57:1419–1426.
Leahy JL: Mary, Mary, quite contrary, how do your beta-cells fail?
Diabetes 2008, 57:2563–2564.
Lyssenko V, Lupi R, Marchetti P, et al.: Mechanisms by which common variants in the TCF7L2 gene increase risk of type 2 diabetes. J Clin Invest 2007, 117:2155–2163.
Chimienti F, Devergnas S, Pattou F, et al.: In vivo expression and functional characterization of the zinc transporter ZnT8 in glucose-induced insulin secretion. J Cell Sci 2006, 119:4199–4206.
Krishnamurthy J, Ramsey MR, Ligon KL, et al.: p16INK4a induces an age-dependent decline in islet regenerative potential. Nature 2006, 443:453–457.
Barrett JC, Hansoul S, Nicolae DL, et al.: Genome-wide association defines more than 30 distinct susceptibility loci for Crohn’s disease. Nat Genet 2008, 40:955–962.
Thomas G, Jacobs KB, Yeager M, et al.: Multiple loci identified in a genome-wide association study of prostate cancer. Nat Genet 2008, 40:310–315.
Finkel T, Serrano M, Blasco MA: The common biology of cancer and ageing. Nature 2007, 448:767–776.
Kasper JS, Giovannucci E: A meta-analysis of diabetes mellitus and the risk of prostate cancer. Cancer Epidemiol Biomarkers Prev 2006, 15:2056–2062.
Lango H; UK Type 2 Diabetes Genetics Consortium, Palmer CN, et al.: Assessing the combined impact of 18 common genetic variants of modest effect sizes on type 2 diabetes risk. Diabetes 2008, 57:3129–3135.
Gloyn AL, Pearson ER, Antcliff JF, et al.: Activating mutations in the gene encoding the ATP-sensitive potassium-channel subunit Kir6.2 and permanent neonatal diabetes. N Engl J Med 2004, 350:1838–1849.
Pearson ER, Flechtner I, Njølstad PR, et al.: Switching from insulin to oral sulfonylureas in patients with diabetes due to Kir6.2 mutations. N Engl J Med 2006, 355:467–477.
Pearson ER, Donnelly LA, Kimber C, et al.: Variation in TCF7L2 influences therapeutic response to sulfonylureas: a GoDARTs study. Diabetes 2007, 56:2178–2182.