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Nutrigenetics of Blood Cholesterol Concentrations: Towards Personalized Nutrition

  • Public Health Policy (E Klodas, Section Editor)
  • Published:
Current Cardiology Reports Aims and scope Submit manuscript

Abstract

Purpose of the Review

To summarize achievements made in the field of nutrigenetics to personalized nutrition. Moreover, the limitations and challenges observed to enable clinical utilization are discussed.

Recent Findings

Currently, with the availability of low-cost genetic testing and new bioinformatics tools, significant developments have occurred to allow issues inherent to the highly complex nature of genetic data to be tackled. Moreover, new statistical methods have uncovered combinatory patterns of SNPs that collectively explain the high interindividual variability in response to dietary interventions. Yet, the application of these results to personalized dietary recommendations is not straightforward.

Summary

Data from gene-nutrient interaction studies have provided evidence to understand the inter-individual variation differences in blood cholesterol responses. A need exists for guidelines and regulations in order to apply nutrigenetics to personalized nutrition. Moreover, a multisystem approach including genetics, microbiome and environment is needed to achieve possible practical applications.

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Acknowledgments

The authors thank Stephanie Jew for her helpful input and for her scientific writing assistance in the development of this article.

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Authors and Affiliations

  1. Richardson Centre for Functional Foods and Nutraceuticals, University of Manitoba, 196 Innovation Drive, Winnipeg, Manitoba, R3T 6C5, Canada

    Itzel Vazquez-Vidal & Peter J. H. Jones

  2. Aix Marseille Univ, INRA, INSERM, C2VN, Marseille, France

    Charles Desmarchelier

  3. Department of Food and Human Nutritional Sciences, University of Manitoba, Winnipeg, Manitoba, Canada

    Peter J. H. Jones

Authors
  1. Itzel Vazquez-Vidal
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  2. Charles Desmarchelier
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  3. Peter J. H. Jones
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Corresponding author

Correspondence to Peter J. H. Jones.

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Conflict of Interest

Itzel Vazquez-Vidal and Charles Desmarchelier declare that they have no conflict of interest. Peter J. H Jones has received research grants from Nutritional Fundamentals for Health Inc., Mitacs, and the International Life Sciences Institute. He also owns stock in Nutritional Fundamentals for Health Inc.

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Vazquez-Vidal, I., Desmarchelier, C. & Jones, P.J.H. Nutrigenetics of Blood Cholesterol Concentrations: Towards Personalized Nutrition. Curr Cardiol Rep 21, 38 (2019). https://doi.org/10.1007/s11886-019-1124-x

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