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Double-Trouble: Atherosclerotic Risk Factors and Congenital Heart Disease

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Abstract

Purpose of Review

Youth with congenital heart disease (CHD) are uniquely vulnerable to genetic and acquired atherosclerotic cardiovascular disease (ASCVD) risk factors. With the increasingly successful management of CHD, it is important to prevent or optimally managed risk factors with the goal of improving outcomes and longevity.

Recent Findings

This review summarizes guidelines for the evaluation and management of obesity, dyslipidemia, and hypertension in youth (< 18 years of age), focusing on the special vulnerabilities associated with the type of repair and the presence of residual disease in those who undergo cardiac surgery.

Summary

Clinicians must focus on targeting these highly prevalent ASCVD risk factors to protect CHD survivors from preventable ASCVD morbidity and mortality by applying lifestyle, pharmacologic, or surgical therapies as needed. Future work should examine interventions to identify and treat ASCVD risk factors in CHD patients. Given the increased prevalence of ASCVD risk factors in youth and the morbidity and premature mortality associated with CHD, it is important for clinicians to assess global risk factors in these patients frequently, encourage adherence to lifestyle changes, and recommend pharmacotherapy and surgical interventions when clinically indicated. Future efforts should identify barriers and opportunities for improving risk factor assessment and timely intervention as a routine part of clinical care.

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This work was supported by the National Heart, Lung, and Blood Institute R01 HL148217 (J. P. Z.).

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  1. Section of Pediatric Cardiology, Department of Pediatrics, Texas Children’s Hospital, Baylor College of Medicine, Houston, TX, 77030, USA

    Justin P. Zachariah

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Zachariah, J.P. Double-Trouble: Atherosclerotic Risk Factors and Congenital Heart Disease. Curr Atheroscler Rep 25, 417–426 (2023). https://doi.org/10.1007/s11883-023-01114-1

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