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The therapeutic potential of high-density lipoprotein mimetic agents in coronary artery disease

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Abstract

Low levels of high-density lipoprotein cholesterol (HDL-C) represent a major cardiovascular risk factor that is only modestly influenced by currently available drugs. Consequently, there has been interest in developing new therapeutic agents specifically targeting HDL-C to reduce risk in patients with coronary artery disease. One strategy involves the administration of therapies that mimic HDL-C or its properties, including reconstituted HDL, apolipoprotein A-I (apoA-I), apoA-I Milano, and apoA-I mimetic peptides. The atheroprotective effects of reconstituted HDL, apoA-I, and apoA-I Milano have been well documented in animal studies, and two recent clinical trials also provided encouraging results. The most investigated apoA-I mimetic peptide, D-4F, was shown to significantly reduce atherosclerotic lesions in animal models but data in humans are scarce. HDL-C mimetic agents constitute a promising novel strategy to reduce coronary artery disease risk but require further study in larger clinical trials.

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Authors and Affiliations

  1. Department of Medicine and Research Center, Montreal Heart Institute, 5000 Belanger Street, Montreal, H1T 1C8, QC, Canada

    Jean-Claude Tardif

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  1. Philippe Meyer
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  2. Anil Nigam
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  3. Michel Marcil
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  4. Jean-Claude Tardif
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Correspondence to Jean-Claude Tardif.

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Meyer, P., Nigam, A., Marcil, M. et al. The therapeutic potential of high-density lipoprotein mimetic agents in coronary artery disease. Curr Atheroscler Rep 11, 329–333 (2009). https://doi.org/10.1007/s11883-009-0049-z

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