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Proteomics in atherosclerosis

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Abstract

Atherothrombosis is the underlying cause of several clinical manifestations, such as acute coronary syndromes, cerebrovascular disease, and peripheral artery disease, which together are the leading cause of death in the Western world. Proteins from vascular cells or atherosclerotic plaques that are present in plasma are modified along the different steps of atherosclerotic development and constitute target candidates for vascular research, particularly in the search for novel biological markers of cardiovascular risk. In this review, we summarize proteomic techniques and the most recent results obtained by application of these high-throughput strategies to cardiovascular samples.

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Authors and Affiliations

  1. Vascular Research Laboratory, Fundación Jiménez Díaz, Avenida Reyes Católicos 2, 28040, Madrid, Spain

    Jesus Egido

Authors
  1. Roxana Martinez-Pinna
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  2. Jose Luis Martin-Ventura
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  3. Sebastian Mas
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  4. Luis Maria Blanco-Colio
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  5. Jose Tuñon
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  6. Jesus Egido
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Correspondence to Jesus Egido.

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Martinez-Pinna, R., Martin-Ventura, J.L., Mas, S. et al. Proteomics in atherosclerosis. Curr Atheroscler Rep 10, 209–215 (2008). https://doi.org/10.1007/s11883-008-0033-z

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