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ACE Inhibitor–Induced Angioedema


Much has been written about hereditary angioedema (HAE) in recent literature; however, the prevalence of angiotensin-converting enzyme inhibitor–induced angioedema (ACEiIA) far exceeds that of HAE. Similarly, multiple therapies have been developed for HAE, yet no definitive therapy is available for ACEiIA. In this article, we discuss the mechanism, prevalence, pathophysiology, and management of ACEiIA, with focus on newer therapies recently approved for HAE and how they may be effective for ACEiIA.

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Papers of particular interest, published recently, have been highlighted as: • Of importance •• Of major importance

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Dr. Craig has received research grant support from GlaxoSmithKline, Genentech, Novartis, Boehringer Ingelheim, Dyax Corp., CSL Behring, ViroPharma, Shire, and Pharming Group NV; has served as a consultant for Merck & Co., Novartis, CSL Behring, ViroPharma, Shire, and Dyax Corp.; has served as a speaker for ViroPharma, CSL Behring, and Dyax Corp.; has served on boards for the American Academy of Allergy, Asthma and Immunology, American College of Allergy, Asthma and Immunology, ALA-PA, and the Joint Council of Allergy, Asthma and Immunology; and has received salary support from the Vietnam Education Foundation.

Dr. Vasekar reported no potential conflicts of interest relevant to this article.

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Correspondence to Timothy J. Craig.

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Vasekar, M., Craig, T.J. ACE Inhibitor–Induced Angioedema. Curr Allergy Asthma Rep 12, 72–78 (2012).

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  • Angioedema
  • ACEi–induced angioedema
  • Hereditary angioedema
  • Angiotensin-converting enzyme inhibitor
  • Icatibant
  • Ecallantide