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Serum Elabela level is related to endoscopic activity index in patients with active ulcerative colitis

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Abstract

Background

In ulcerative colitis patients, Elabela levels and the relation of Elabela with laboratory parameters is unknown.

Aim

The purpose of this study was to investigate the serum Elabela levels in UC patients and its relationship with other clinical and laboratory findings.

Methods

Forty-three patients with UC and 40 healthy controls (group I) similar in age and gender were included in the study. Routine patient history, physical examination, and laboratory tests were followed by analysis of serum Elabela levels. Endoscopic activity index (EAI) of patients with UC was calculated. There were two groups of patients: those in remission (group II) and with active disease (group III).

Results

Groups I, II, and III had 40, 22, and 21 participants, respectively. Serum Elabela levels were found to be 3.32 ± 1.25 ng/mL in group I, 3.38 ± 0.88 ng/mL in group II, and 5.48 ± 1.61 ng/mL in group III. Comparing the serum Elabela levels, a statistically significant difference was found between three groups (p < 0.001). Serum Elabela level showed a significant and positive correlation with EAI, leukocyte count, and hs-CRP, while a negative correlation was found with hemoglobin levels in univariate analysis (p < 0.001, for each). In linear regression analysis, these parameters were found to be associated with EAI and hs-CRP (p = 0.049, β = 0.337, and p = 0.015, β = 0.396, respectively).

Conclusion

Elabela concentrations in patients with active UC was significantly higher and was associated with EAI and hs-CRP. Blood Elabela concentrations can be useful in the diagnosis and follow-up of patients with active UC.

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Authors and Affiliations

  1. Department of Gastroenterology, University of Health Sciences - Adana Health Practice and Research Center, Adana, Turkey

    Erdinc Gulumsek, Adnan Tas & Banu Kara

  2. Department of Internal Medicine, University of Health Sciences - Adana Health Practice and Research Center, Dr. Mithat Özsan Bulvarı Kışla Mah. 4522 Sok. No: 1 Yüreğir, Adana, Turkey

    Hilmi Erdem Sumbul, Cisem Kizildag, Dilan Damla Ozturk, Begum Seyda Avci & Beytullah Aktas

  3. Department of Medical Biochemistry, Suleyman Yalcin City Hospital, Goztepe Prof. Dr, Istanbul, Turkey

    Fatih Yesildal

  4. Department of Emergency Medicine, University of Health Sciences - Adana Health Practice and Research Center, Adana, Turkey

    Akkan Avci

  5. Department of Infectious Disease, University of Health Sciences - Adana Health Practice and Research Center, Adana, Turkey

    Edip Bayrak

Authors
  1. Erdinc Gulumsek
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  2. Hilmi Erdem Sumbul
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  3. Fatih Yesildal
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  4. Cisem Kizildag
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  5. Dilan Damla Ozturk
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  6. Begum Seyda Avci
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  7. Beytullah Aktas
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  8. Akkan Avci
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  9. Edip Bayrak
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  10. Adnan Tas
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  11. Banu Kara
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Contributions

Conceptualization: EG, HES, AT, EB; methodology: EG, HES, BSA, FY; formal analysis and investigation: CK, DDO, BA; writing—original draft preparation: HES, EG; writing—review and editing: AA, AT, BK; funding acquisition: none; resources: none; supervision: AA, AT, BK. All authors contributed to the study conception and design and all authors commented on previous versions of the manuscript. All authors read and approved the final manuscript.

Corresponding author

Correspondence to Hilmi Erdem Sumbul.

Ethics declarations

The study was performed according to the recommendations set by the The Declaration of Helsinki on Medical Research involving Human Subjects.

Ethical approval

The study was approved by the institutional ethics committee (Adana City Training and Research Hospital Research and Training Hospital, Ethics Committee, Approval date and number: 10.04.2020/98).

Informed consent

Consent forms were explained to all patients in detail by the researchers and the participants were included in the study after giving written consent.

Conflict of interest

The authors declare no competing interests.

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Gulumsek, E., Sumbul, H.E., Yesildal, F. et al. Serum Elabela level is related to endoscopic activity index in patients with active ulcerative colitis. Ir J Med Sci 191, 1171–1176 (2022). https://doi.org/10.1007/s11845-021-02914-7

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  • DOI: https://doi.org/10.1007/s11845-021-02914-7

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