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Effect of calcium and vitamin D supplementation on the clinical, hormonal, and metabolic profile in non-obese women with polycystic ovary syndrome

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Abstract

Background

In this study, we investigated the effect of calcium and vitamin D (Ca/Vit D) supplementation on the clinical, hormonal, and metabolic profile of patients with low vitamin D levels. In addition, we investigated the effect of Ca/Vit D supplementation on asymmetric dimethylarginine (ADMA) level in patients with polycystic ovary syndrome (PCOS).

Methods

In total, 75 patients aged 19–35 years, with a normal body mass index and a diagnosis of PCOS and Vit D deficiency/insufficiency, were included in the study. Patients received 50,000 IU of vitamin D3 once a week for 8 weeks. Afterward, 2500 mg calcium carbonate equivalent to 1000 mg calcium ion and 9.68 mg cholecalciferol equivalent to 880 IU vitamin D3 were administered orally as a maintenance treatment once a day.

Results

The mean age of the patients was 21.7 ± 3.5. After Ca/Vit D supplementation, Vit D levels significantly increased compared to baseline (8.6 ng/ml) levels. An increase in SHBG levels (p < 0.001), a decrease in total testosterone, FAI (p = 0.042), and ADMA levels (p < 0.001) were observed in the first and third months compared to the onset. Significant improvement compared to baseline was observed in menstrual irregularity and median mFG score.

Conclusion

Ca/Vit D supplementation can improve PCOS symptoms such as menstrual dysfunction, hirsutism, and hyperandrogenism. It may be effective in reducing the risk of cardiovascular disease in patients with PCOS later in life by decreasing ADMA levels, which is an indicator of endothelial dysfunction.

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Acknowledgements

The authors thank all the participants in this study.

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Authors and Affiliations

  1. Department of Obstetrics and Gynecology, Aksaray University Education and Research Hospital, Aksaray, Turkey

    Zekiye Soykan Sert

  2. Department of Obstetrics and Gynecology, Faculty of Medicine, Selçuk University, Konya, Turkey

    Setenay Arzu Yılmaz, Özlem Seçilmiş & Çetin Çelik

  3. Department of Biochemistry, Faculty of Medicine, Selçuk University, Konya, Turkey

    Sedat Abuşoğlu & Ali Ünlü

Authors
  1. Zekiye Soykan Sert
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  2. Setenay Arzu Yılmaz
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  3. Özlem Seçilmiş
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  4. Sedat Abuşoğlu
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  5. Ali Ünlü
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  6. Çetin Çelik
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Contributions

ZSS: protocol/project development, data collection and management, data analysis, and manuscript writing. YSA: data collection and management, data analysis and manuscript writing. SÖ: data collection and management. ÜA: data collection and management. AS, ÇÇ: protocol/project development, data analysis, and manuscript writing.

Corresponding author

Correspondence to Zekiye Soykan Sert.

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Ethics approval

This study protocol was approved by the Clinical Research Ethical Committee of Selçuk University Faculty of Medicine with a protocol number of 2015/6 and conducted in accordance with the Declaration of Helsinki and Good Clinical Practices.

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All authors have read and approved the final version of this manuscript and have consented for publication.

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No conflict of interest was declared by the authors.

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Sert, Z.S., Yılmaz, S.A., Seçilmiş, Ö. et al. Effect of calcium and vitamin D supplementation on the clinical, hormonal, and metabolic profile in non-obese women with polycystic ovary syndrome. Ir J Med Sci 191, 2657–2662 (2022). https://doi.org/10.1007/s11845-021-02899-3

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  • DOI: https://doi.org/10.1007/s11845-021-02899-3

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