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We would like to share ideas on the publication “Pre-vaccination immune response to COVID-19 in a population in Northeast Portugal [1].” Duro et al. concluded that “IgM and IgG displayed a similar initial increase … the identification of previously undiagnosed participants. [1].” We agree that the pre-vaccination antibody study might be useful. A diagnosis of previous asymptomatic infection can help gather correct epidemiological data. Additionally, the investigation might be useful for determining vaccine efficacy and surveillance of safety of vaccination. In a previous report, immune response to COVID-19 vaccine differs in cases with and without previous COVID-19 [2]. Additionally, a COVID-19 vaccine recipient with previous COVID-19 has a higher blood viscosity after vaccination, which might lead to hyperviscosity-associated adverse effect of vaccination [2].
References
Duro M, Duro I, Rebelo I et al (2021) Pre-vaccination immune response to COVID-19 in a population in Northeast Portugal. Ir J Med Sci https://doi.org/10.1007/s11845-021-02799-6. Online ahead of print
Joob B, Wiwanitkit V (2021) Viscosity after COVID-19 vaccination, hyperviscosity and previous COVID-19. Clin Appl Thromb Hemost Jan-Dec 27:10760296211020833
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Mungmunpuntipantip, R., Wiwanitkit, V. Pre-vaccination immune response to COVID-19. Ir J Med Sci 191, 2219 (2022). https://doi.org/10.1007/s11845-021-02822-w
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DOI: https://doi.org/10.1007/s11845-021-02822-w