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Resveratrol and cardiovascular system—the unfulfilled hopes

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Abstract

Introduction

Resveratrol is a natural polyphenolic compound with a stilbene structure endowed with multiple health-promoting effects. Among phenolic compounds, resveratrol is assigned a leading role in the health-promoting effects of red wine.

Methods

The aim of the study was to assess the effect of resveratrol on the cardiovascular system in the experimental and clinical studies conducted so far. Moreover, the paper discusses the results of the most recent meta-analyses assessing resveratrol’s therapeutic effect on the cardiovascular system in humans.

Results

In animal and preclinical studies, resveratrol has demonstrated a wide physiological and biochemical spectrum of activity, including antioxidant, anti-inflammatory, antiplatelet, and anticoagulant activities, which translated into its health-promoting effects on the cardiovascular system. The performed meta-analyses allow to confirm such an impact, however, after the assessment with the use of the SYRCLE’s tool, these studies are burdened with a high risk of bias, and the results are not clearly presented.

Conclusion

Despite numerous articles and clinical studies, the convincing beneficial mechanisms of resveratrol as well as its health-promoting effects in cardiovascular diseases have not been clearly confirmed in humans. Therefore, there is a need for further clinical studies, especially randomized, double-blind, placebo-controlled trials to objectively confirm the possible health-promoting effects of this substance and to determine both the efficacy and safety, and possible therapeutic potential.

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Authors and Affiliations

  1. Department of Nutrition and Dietetics, Ludwik Rydygier Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University in Toruń, 3 Dębowa Street, 85-626, Bydgoszcz, Poland

    Małgorzata Chudzińska

  2. Department of Cardiology and Clinical Pharmacology, Ludwik Rydygier Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University in Toruń, 75 Ujejskiego Street, 85-168, Bydgoszcz, Poland

    Daniel Rogowicz, Łukasz Wołowiec, Joanna Banach, Sławomir Sielski, Robert Bujak & Grzegorz Grześk

  3. Department of Phoniatrics and Audiology, Ludwik Rydygier Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University in Toruń, 75 Ujejskiego Street, 85-168, Bydgoszcz, Poland

    Anna Sinkiewicz

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MC—conception and design of the article, interpreting the relevant literature, drafting of manuscript;

DR—conception and design of the article, interpreting the relevant literature, drafting of manuscript;

ŁW—interpreting the relevant literature, drafting of manuscript;

JB—interpreting the relevant literature, drafting of manuscript;

SS—conception and design of the article, interpreting the relevant literature;

RB—literature review, drafting of manuscript;

AS—literature review, critical revision;

GG—critical revision, proofreading of the version for publication.

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Chudzińska, M., Rogowicz, D., Wołowiec, Ł. et al. Resveratrol and cardiovascular system—the unfulfilled hopes. Ir J Med Sci 190, 981–986 (2021). https://doi.org/10.1007/s11845-020-02441-x

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