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Kidney-gut crosstalk in renal disease

  • Review Article
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Irish Journal of Medical Science (1971 -) Aims and scope Submit manuscript

Abstract

Introduction

The colon has an important role in managing nitrogenous waste products, electrolytes, and mineral balance during kidney diseases. However, colonic microbiota produces uremic toxins, such as indoxyl sulfate and p-cresyl sulfate, in chronic kidney disease (CKD) patients, which due to their proinflammatory properties contribute to CKD progression. Conversely, in acute renal injury patients, intestinal microbiota could reduce inflammation by secreting short-chain fatty acids and inducing a renal protective immune response. However, since the intestines are the most frequently affected organ in advanced sepsis, colonic microbiota can also represent a negative factor for kidney health in this scenario.

Conclusion

In the present review, the main characteristics of kidney-gut crosstalk are described.

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Authors and Affiliations

  1. Human Physiology Department, Instituto Universitario del Hospital Italiano de Buenos Aires, Buenos Aires, Argentina

    Iara Colombo, Florencia Aiello-Battan, Rosario Elena, Agustina Ruiz & Carlos G. Musso

  2. Nephrology Residency, Nephrology Division, Hospital Universitario CEMIC, Buenos Aires, Argentina

    Lucas Petraglia

  3. Facultad de Ciencias de la Salud, Universidad Simon Bolivar, Barranquilla, Colombia

    Carlos G. Musso

  4. Ageing Biology Unit, Hospital Italiano de Buenos Aires, Buenos Aires, Argentina

    Carlos G. Musso

Authors
  1. Iara Colombo
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  2. Florencia Aiello-Battan
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  3. Rosario Elena
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  4. Agustina Ruiz
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  5. Lucas Petraglia
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  6. Carlos G. Musso
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Correspondence to Carlos G. Musso.

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Colombo, I., Aiello-Battan, F., Elena, R. et al. Kidney-gut crosstalk in renal disease. Ir J Med Sci 190, 1205–1212 (2021). https://doi.org/10.1007/s11845-020-02437-7

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  • DOI: https://doi.org/10.1007/s11845-020-02437-7

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