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Post-transplant diabetes mellitus associated with heart and lung transplant

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Irish Journal of Medical Science (1971 -) Aims and scope Submit manuscript

Abstract

Background

The incidence of post-transplant diabetes (PTDM) is variable primarily due to a lack of standardised diagnostic criteria.

Aim

This study aimed to assess the incidence of PTDM in heart and lung transplant (HLT) patients and to review if the management of these patients is in accordance with the 2014 American Society of Transplantation guidelines.

Methods

This was a retrospective study in the Mater Misericordiae University Hospital, Dublin, Ireland. Data was collected from the patients who had undergone HLT.

Results

All patients who had a heart and/or lung transplant between 2005 and 2017 were identified. The majority of our patients had lung 111 (53.9%), heart 94 (45.6%) and combined heart/lung 1(0.5%) transplants. A total of 174 (84.5%) patients were screened for diabetes pre-transplantation. Two hundred five (99.9%) patients were screened for PTDM post-surgery. The cumulative incidence for PTDM was 19.4% (40/206). All patients with PTDM were on prednisolone, 32 (80%) on tacrolimus and 4 (10%) on cyclosporine.

Conclusions

The cumulative incidence of post-transplant diabetes in our cohort was 19.4%. The majority of the patients were screened before and after transplant for glucose abnormality. The authors recommend that all patients should be managed in a multidisciplinary setting including transplant physicians, endocrinlogist, diabetes nurse specialists, transplant nurses and dietitians.

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Acknowledgements

The authors would like to thank the patients involved in this study.

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Authors and Affiliations

  1. Department of Endocrinology, Mater Misericordiae University Hospital, Dublin, Ireland

    Oratile Kgosidialwa & Mensud Hatunic

  2. School of Medicine, University College Dublin, Dublin, Ireland

    Kieran Blake, Oisin O’Connell, Jim Egan, Jim O’Neill & Mensud Hatunic

  3. Department of Respiratory Medicine and Lung & Heart Transplantation, Mater Misericordiae University Hospital, Dublin, Ireland

    Oisin O’Connell & Jim Egan

  4. Department of Cardiology, Mater Misericordiae University Hospital, Dublin, Ireland

    Jim O’Neill

Authors
  1. Oratile Kgosidialwa
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  2. Kieran Blake
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  3. Oisin O’Connell
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  4. Jim Egan
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  5. Jim O’Neill
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  6. Mensud Hatunic
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Correspondence to Mensud Hatunic.

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Kgosidialwa, O., Blake, K., O’Connell, O. et al. Post-transplant diabetes mellitus associated with heart and lung transplant. Ir J Med Sci 189, 185–189 (2020). https://doi.org/10.1007/s11845-019-02068-7

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  • DOI: https://doi.org/10.1007/s11845-019-02068-7

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