Abstract
Aims
To study the nature of the tumours managed in the Irish population.
Methods
This audit research was completed via a retrospective medical review on 200 patients with CNS tumours managed in a tertiary care centre between 2008 and 2009.
Results
The mean age was 53 years. The male:female ratio was 2:1. The majority were glioblastomas and astrocytomas. Grade IV tumours were predominant (65.5 %). Headaches (37 %), motor weakness (32 %) and seizures (25.5 %) were the highest presentations. The commonest sites affected were the left parietal and left temporal lobes. There were 17.5 % operative morbidities with motor weakness (22.9 %), seizure (14.3 %) and thrombo-embolism (14.3 %) dominating and significant association to surgical radicality (p = 0.041). 3.5 % operative mortalities were reported. 52.5 and 62.5 % of patients received adjuvant chemotherapy and radiotherapy, respectively.
Conclusions
Patients with CNS tumours typically had multiple presentations. More extensive surgical resection was associated with higher postoperative morbidities (p = 0.041). The 30-day postoperative morbidity (17.5 %) and mortality (3.5 %) were concordant with the currently available literature.
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References
Brain and other CNS trends (2010). http://www.ncri.ie/pubs/pubfiles/Brain%20and%20other%20CNS%20trends.pdf
Ogungbo BI, Najim O, Mendelow AD et al (2002) Epidemiology of adult brain tumours in Great Britain and Ireland. Br J Neurosurg 16(2):140–145
Sawaya R (2004) Chairman’s reflection on the past, present and future of neurosurgical oncology. J Neurooncol 69:19–23
Shortage of neurosurgeons leaves two-year waiting list for vital surgery (2010) https://www.tribune.ie/archive/article/2007/dec/09/shortage-of-neurosurgeons-leaves-two-year-waiting-/
Bruneau M, Bijlenga P, Reverdin A et al (2006) Early surgery for brainstem cavernomas. Acta Neurochir (Wien) 148:405–414 (Epub 2005 Nov 28)
GraphPad QuickCalcs: free statistical calculators (2011).http://www.graphpad.com/quickcalcs/index.cfm
Louis DN, Ohgaki H, Wiestler OD et al (2007) The 2007 WHO classification of tumours of the central nervous system. Acta Neuropathol 114:97–109 (Epub 2007 Jul 6)
Kohler BA, Ward E, McCarthy BJ et al (2011) Annual report to the nation on the status of cancer, 1975–2007, featuring tumors of the brain and other nervous system. J Natl Cancer Inst 103:714–736. doi:10.1093/jnci/djr077
Wrensch M, Minn Y, Chew T et al (2002) Epidemiology of primary brain tumors: current concepts and review of the literature. Neuro Oncol 4:278–299
Davis FG, Kupelian V, Freels S et al (2001) Prevalence estimates for primary brain tumors in the United States by behavior and major histology groups. Neuro Oncol 3:152–158
Crowley MJ, O’Brien DF (1993) Epidemiology of tumours of the central nervous system in Ireland. Ir Med J 86:87–88
Forsyth PA, Posner JB (1993) Headaches in patients with brain tumors: a study of 111 patients. Neurology 43:1678–1683
Purdy RA, Kirby S (2004) Headaches and brain tumors. Neurol Clin 22:39–53
Pfund Z, Szapáry L, Jászberényi O et al (1999) Headache in intracranial tumors. Cephalalgia 19:787–790 (discussion 765)
Wilne SH, Ferris RC, Nathwani A et al (2006) The presenting features of brain tumours: a review of 200 cases. Arch Dis Child 91:502–506
Engelhard HH, Villano JL, Porter KR et al (2010) Clinical presentation, histology, and treatment in 430 patients with primary tumors of the spinal cord, spinal meninges, or cauda equina. J Neurosurg Spine 13:67–77. doi:10.3171/2010.3.SPINE09430
Neervoort FW, Ouwerkerk WJR, Folkersma H et al (2010) Surgical morbidity and mortality of pediatric brain tumors: a single center audit. Childs Nerv Syst 26:1583–1592. doi:10.1007/s00381-010-1086-1
Chaichana KL, Garzon-Muvdi T, Parker S et al (2011) Supratentorial glioblastoma multiforme: the role of surgical resection versus biopsy among older patients. Ann Surg Oncol 18:239–245. doi:10.1245/s10434-010-1242-6 (Epub 2010 Aug 10)
Patil CG, Pricola K, Garg SK et al (2010) Whole brain radiation therapy (WBRT) alone versus WBRT and radiosurgery for the treatment of brain metastases. Cochrane Database Syst Rev 16:CD006121. doi:10.1002/14651858.CD006121
Hart MG, Grant R, Walker M et al (2005) Surgical resection and whole brain radiation therapy versus whole brain radiation therapy alone for single brain metastases. Cochrane Database Syst Rev 1:CD003292
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Muhamat Nor, F.E., Chandrasekaran, K. & Marks, J.C. A retrospective audit of 200 cases of CNS tumours and their surgical management in a tertiary care centre. Ir J Med Sci 182, 697–701 (2013). https://doi.org/10.1007/s11845-013-0959-1
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DOI: https://doi.org/10.1007/s11845-013-0959-1