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Pneumococcal meningitis: clinical outcomes in a pre-vaccine era at a Dublin paediatric hospital, 1999–2007

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Abstract

Aim

To document the long-term outcomes of pneumococcal meningitis in children presenting to a Dublin paediatric hospital in the pre-pneumococcal conjugate vaccine (PCV7) era (1998–2007).

Methods

Subjects with pneumococcal meningitis were identified at The Children’s University Hospital, Dublin through the hospital surveillance system and laboratory archives.

Results

44 children were identified with S. pneumoniae meningitis. Mean age of presentation was 23.45 months (2 days to 13 years) and 28 (65%) cases were less than 12 months old. Eight (18.6%) children died. 55% of cases were left with significant deficits. Of the survivors, 7 (20%) had moderate to severe neurological sequelae.

Conclusion

Pneumococcal meningitis is a devastating childhood disease with significant mortality and morbidity, especially in those less than 2 years of age. These data provide a baseline against which the impact of PCV7 on pneumococcal meningitis can be measured.

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References

  1. Jefferson T, Ferroni E, Curtale F et al (2006) Streptococcus pneumoniae in Western Europe: serotype distribution and incidence in children less than 2 years old. Lancet Infect Dis 6:405–410

    Article  PubMed  Google Scholar 

  2. Swartz MN (2004) Bacterial meningitis—a view of the past 90 years. N Engl J Med 351:1826–1828

    Article  CAS  PubMed  Google Scholar 

  3. Arditi M, Mason EO, Bradley JS et al (1998) Three-year multicenter surveillance of pneumococcal meningitis in children: clinical characteristics, and outcome related to penicillin susceptibility and dexamethasone use. Pediatrics 102:1087–1097

    Article  CAS  PubMed  Google Scholar 

  4. Feikin DR, Klugman KP. Historical changes in pneumococcal serogroup distribution: implications for the era of pneumococcal conjugate vaccines. Clin Infect Dis 2002; 35: 547–55

    Google Scholar 

  5. Hausdorff WP, Bryant J, Paradiso PR et al (2000) Which pneumococcal serogroups cause the most invasive disease: implications for conjugate vaccine formulation and use, part 1. Clin Infect Dis 30:100–121

    Article  CAS  PubMed  Google Scholar 

  6. Hausdorff WP, Bryant J, Kloek C et al (2000) The contribution of specific pneumococcal serogroups to different disease manifestations: implications for conjugate vaccine formulation and use, part 2. Clin Infect Dis 30:122–140

    Article  CAS  PubMed  Google Scholar 

  7. Fitzsimons JJ, Chong AL, Cafferkey MT, Butler KM (2008) Invasive pneumococcal disease in children in Ireland—the anticipated benefit of conjugate pneumococcal vaccination. IrJ Med Sci. 177(3):225–231 Epub 2008 Jun 27

    Article  CAS  Google Scholar 

  8. McIntyre PB, Macintyre CR, Gilmour R, Wang H (2005) A population based study of the impact of corticosteroid therapy and delayed diagnosis on the outcome of childhood pneumococcal meningitis. Arch Dis Child 90(4):391–396

    Article  CAS  PubMed  Google Scholar 

  9. van de Beek D, de Gans J, McIntyre P, Prasad K. Corticosteroids for acute bacterial meningitis. Cochrane Database Syst Rev. 2007 Jan 24;(1):CD004405

  10. Centers for Disease Control and Prevention (CDC) (2008) Invasive pneumococcal disease in children 5 years after conjugate vaccine introduction–eight states, 1998-2005. MMWR Morb Mortal Wkly Rep 57(6):144–148

    Google Scholar 

  11. Perrocheau A, De Benoist AC, Six C et al (2002) Epidemiology of bacterial meningitis in France in 1999. Ann Med Interne 153:311–317

    Google Scholar 

  12. Ada G (2001) Vaccines and vaccination. N Engl J Med 345(14):1042–1053

    Article  CAS  PubMed  Google Scholar 

  13. Musher DM (2006) Pneumococcal vaccine—direct and indirect (“herd”) effects. N Engl J Med 354(14):1522–1524

    Article  CAS  PubMed  Google Scholar 

  14. Hicks LA, Harrison LH, Flannery B et al (2007) Incidence of pneumococcal disease due to non-pneumococcal conjugate vaccine (PCV7) serotypes in the United States during the era of widespread PCV7 vaccination, 1998–2004. J Infect Dis 196(9):1346–1354 Epub 2007 Oct 4

    Article  PubMed  Google Scholar 

  15. Scott DA, Komjathy SF, Hu BT, Baker S, Supan LA, Monahan CA, Gruber W, Siber GR, Lockhart SP (2007) Phase 1 trial of a 13-valent pneumococcal conjugate vaccine in healthy adults. Vaccine 25(33):6164–6166 Epub 2007 Jun 26

    Article  CAS  PubMed  Google Scholar 

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Authors and Affiliations

  1. Department of Paediatrics, Children’s University Hospital, Temple Street, Dublin 1, Ireland

    J. M. Lucey, P. Gavin, M. Cafferkey & K. M. Butler

  2. Department of Clinical Microbiology, Children’s University Hospital, Temple Street, Dublin 1, Ireland

    M. Cafferkey

  3. Department of Paediatrics, Princess Margaret Children’s Hospital, Robert’s Rd, Subiaco, Perth, 6008, WA, Australia

    J. M. Lucey

Authors
  1. J. M. Lucey
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  2. P. Gavin
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  3. M. Cafferkey
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  4. K. M. Butler
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Corresponding author

Correspondence to J. M. Lucey.

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Lucey, J.M., Gavin, P., Cafferkey, M. et al. Pneumococcal meningitis: clinical outcomes in a pre-vaccine era at a Dublin paediatric hospital, 1999–2007. Ir J Med Sci 180, 47–50 (2011). https://doi.org/10.1007/s11845-010-0620-1

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  • DOI: https://doi.org/10.1007/s11845-010-0620-1

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