JOM

, Volume 64, Issue 4, pp 520–525 | Cite as

Ultrananocrystalline Diamond-Coated Microporous Silicon Nitride Membranes for Medical Implant Applications

  • Shelby A. Skoog
  • Anirudha V. Sumant
  • Nancy A. Monteiro-Riviere
  • Roger J. Narayan
Article

Abstract

Ultrananocrystalline diamond (UNCD) exhibits excellent biological and mechanical properties, which make it an appropriate choice for promoting epidermal cell migration on the surfaces of percutaneous implants. We deposited a ~150 nm thick UNCD film on a microporous silicon nitride membrane using microwave plasma chemical vapor deposition. Scanning electron microscopy and Raman spectroscopy were used to examine the pore structure and chemical bonding of this material, respectively. Growth of human epidermal keratinocytes on UNCD-coated microporous silicon nitride membranes and uncoated microporous silicon nitride membranes was compared using the 3-(4,5-dimethylthiazol-2-yl)2,5-diphenyltetrazolium bromide (MTT) assay. The results show that the UNCD coating did not significantly alter the viability of human epidermal keratinocytes, indicating potential use of this material for improving skin sealing around percutaneous implants.

References

  1. 1.
    M. Jacobsson and A. Tjellstrom, Clinical Applications of Percutaneous Implants (Lancaster: Technomic, 1991).Google Scholar
  2. 2.
    V. Mooney, S.A. Schwartz, A.M. Roth, and M.J. Goriowsky, Ann. Biomed. Eng. 5, 34 (1977).CrossRefGoogle Scholar
  3. 3.
    A. Rogers and L.B. Morris, Trans. Am. Soc. Artif. Internal. Organs. 13, 146 (1967).Google Scholar
  4. 4.
    G.E. Striker and H.A.M. Tenckhoff, Surgery 69, 70 (1971).Google Scholar
  5. 5.
    B. Holt, A. Tripathi, and J. Morgan, J. Biomech. 41, 2689 (2008).CrossRefGoogle Scholar
  6. 6.
    R. Swain, G. Faulkner, D. Raboud, and J. Wolfaardt, Int. J. Oral Maxillofac. Implants 23, 263 (2008).Google Scholar
  7. 7.
    P.K. Tomaszewski, N. Verdonschot, S.K. Bulstra, and G.J. Verkerke, Ann. Biomed. Eng. 38, 2418 (2010).CrossRefGoogle Scholar
  8. 8.
    M.J.F. de Wolf, M.K.S. Hol, P.L.M. Huygen, E.A.M. Mylanus, and C.W.R.J. Cremers, Otol. Neurotol. 29, 1100 (2008).CrossRefGoogle Scholar
  9. 9.
    P. Fleckman and J.E. Olerud, Biomed. Mater. 3, 034006 (2008).CrossRefGoogle Scholar
  10. 10.
    M.C. Snyder, G.F. Moore, and P.J. Johnson, Otol. Neurotol. 24, 255 (2003).CrossRefGoogle Scholar
  11. 11.
    A.F. von Recum and J.B. Park, CRC Crit. Rev. Bioeng. 5, 37 (1981).Google Scholar
  12. 12.
    G. Winter, J. Biomed. Mater. Res. Symp. 5, 99 (1974).CrossRefGoogle Scholar
  13. 13.
    A.F. von Recum, J. Biomed. Mater. Res. 18, 323 (1984).CrossRefGoogle Scholar
  14. 14.
    V.L. Mooney, P.K. Predecki, J. Renning, and J. Gray, J. Biomed. Mater. Res. Symp. 2, 143 (1971).CrossRefGoogle Scholar
  15. 15.
    V.L. Mooney, D.B. Hartman, D. McNeal, and J. Benson, Arch. Surg. 108, 148 (1974).CrossRefGoogle Scholar
  16. 16.
    A. Haubold, Ann. N. Y. Acad. Sci. 283, 383 (1977).CrossRefGoogle Scholar
  17. 17.
    O. Tagusari, K. Yamazaki, P. Litwak, A. Kojima, E.C. Klein, J.F. Antaki, M. Watach, L.M. Gordon, K. Kono, T. Mori, H. Koyanagi, B.P. Griffith, and R.L. Kormos, Artif. Organs 22, 481 (1998).CrossRefGoogle Scholar
  18. 18.
    T.A. Krouskop, R. Trono, J.C. Norman, G.R. Romovacek, and J.A. Shively, Proceedings of the Fourth Annual Meeting of the Society for Biomaterials (San Antonio, TX: Society For Biomaterials, 1978), pp. 107.Google Scholar
  19. 19.
    T.A. Krouskop, H.D. Brown, K. Gray, J. Shively, G.R. Romovacek, M. Spira, and R.S. Runyan, Biomaterials 9, 398 (1988).CrossRefGoogle Scholar
  20. 20.
    B. Nowicki, R.S. Runyan, N. Smith, and T.A. Krouskop, Biomaterials 11, 389 (1990).CrossRefGoogle Scholar
  21. 21.
    R.J. Narayan, R.D. Boehm, and A.V. Sumant, Mater. Today 14, 154 (2011).CrossRefGoogle Scholar
  22. 22.
    D.M. Gruen, MRS Bull. 26, 771 (2001).Google Scholar
  23. 23.
    S. Jiao, A. Sumant, M.A. Kirk, D.M. Gruen, A.R. Krauss, and O. Auciello, J. Appl. Phys. 90, 118 (2001).CrossRefGoogle Scholar
  24. 24.
    M.A. Hamilton, A.R. Konicek, D.S. Grierson, A.V. Sumant, O. Auciello, W.G. Sawyer, and R.W. Carpick, Proceedings of the STLE/ASME International Joint Tribology Conference (IJTC2008), no. 43369 (Miami, 2008), p. 9.Google Scholar
  25. 25.
    P. Bajaj, D. Akin, A. Gupta, D. Sherman, B. Shi, O. Auciello, and R. Bashir, Biomed. Microdev. 9, 787 (2007).CrossRefGoogle Scholar
  26. 26.
    X. Xiao, J. Wang, C. Liu, J.A. Carlisle, B. Mech, R. Greenberg, D. Guven, R. Freda, M.S. Humayun, J. Weiland, and O. Auciello, J. Biomed. Mater. Res. B Appl. Biomater. 77B, 273 (2006).CrossRefGoogle Scholar
  27. 27.
    O. Makarova, R. Divan, N. Moldovan, D. Rosenmann, and C.M. Tang, J. Vac. Sci. Technol. B 28, C6P42 (2010).CrossRefGoogle Scholar
  28. 28.
    M. Jacoby, Making films one layer at a time: applications of atomic layer deposition now extend well beyond electronics. Chemical & Engineering News 89(31), pp. 38–40. http://pubs.acs.org/cen/science/89/8931sci1.html?from_TRM_site=Lanthanum. Accessed 19 March 2012.
  29. 29.
    A.V. Sumant, O. Auciello, H.C. Yuan, Z. Ma, R.W. Carpick, and D.C. Mancini, 7318, 731817 (2009).Google Scholar
  30. 30.
    N.N. Naguib, J.W. Elam, J. Birrell, J. Wang, D.S. Grierson, B. Kabius, J.M. Hiller, A.V. Sumant, R.W. Carpick, O. Auciello, and J.A. Carlisle, Chem. Phys. Lett. 430, 345 (2006).CrossRefGoogle Scholar
  31. 31.
    C.S. Abreu, F.J. Oliveira, M. Belmonte, A.J.S. Fernandes, R.F. Silva, and J.R. Gomes, Wear 259, 771 (2005).CrossRefGoogle Scholar
  32. 32.
    B. Shen, F. Sun, and G. Yang, Adv. Mater. Res. 135, 143 (2010).CrossRefGoogle Scholar
  33. 33.
    S. Roy and A.J. Fleischman, Sens. Mater. 15, 335 (2003).Google Scholar
  34. 34.
    B. Cappi, S. Neuss, J. Salber, R. Telle, R. Knuchel, and H. Fischer, J. Biomed. Mater. Res. A 93A, 67 (2010).Google Scholar
  35. 35.
    A. Neumann, K. Jahnke, H.R. Maier, and C. Ragoss, Laryngorhinootologie 83, 845 (2004).CrossRefGoogle Scholar
  36. 36.
    PELCO® Holey Silicon Nitride Support Film for TEM. http://www.tedpella.com/grids_html/silicon-nitride-holey.htm. Accessed 19 March 2012.
  37. 37.
    PELCO® Silicon Nitride Support Films for TEM. http://www.tedpella.com/grids_html/silicon-nitride.htm#_21500_10. Accessed 19 March 2012.
  38. 38.
    T. Mossman, J. Immunol. Methods 65, 55 (1983).CrossRefGoogle Scholar
  39. 39.
    Sumant et al. US Patent Application# 13248074.Google Scholar
  40. 40.
    W. Kulisch, C. Popov, H. Rauscher, M. Rinke, and M. Veres, Diam. Relat. Mater. 20, 1076 (2011).CrossRefGoogle Scholar
  41. 41.
    P. Csikvari, A. Somogyi, M. Veres, Gy. Hárs, and A. Tóth, Diam. Relat. Mater. 18, 1459 (2009).CrossRefGoogle Scholar
  42. 42.
    Y.S. Zou, Z.X. Li, and Y.F. Wu, Vacuum 84, 1347 (2010).CrossRefGoogle Scholar
  43. 43.
    R. Arenal, G. Montagnac, P. Bruno, and D.M. Gruen, Phys. Rev. B 76, 245316 (2007).CrossRefGoogle Scholar
  44. 44.
    C.J. Pendegrass, A.E. Goodship, and G.W. Blunn, Biomaterials 27, 4183 (2006).CrossRefGoogle Scholar
  45. 45.
    G. Stynes, G.K. Kiroff, W.A.J. Morrison, and M.A. Kirkland, ANZ J. Surg. 78, 654 (2008).CrossRefGoogle Scholar
  46. 46.
    T. Ohsawa, I. Maruyama, and T. Senshu, J. Dermatol. Sci. 19, 68 (1999).CrossRefGoogle Scholar
  47. 47.
    Y. Pu, J.A. Bernstein, L.I. Bernstam, and R.L. Bronaugh, In Vitro Cell Dev. Biol. Anim. 31, 283 (1995).CrossRefGoogle Scholar
  48. 48.
    L.I. Bernstam, F.L. Vaughan, and I.A. Bernstein, J. Dermatol. Sci. 1, 173 (1990).CrossRefGoogle Scholar
  49. 49.
    L.S. Rhoads, J. Toxicol. Cutan. Ocul. Toxicol. 13, 231 (1994).CrossRefGoogle Scholar
  50. 50.
    L.S. Rhoads, J.R. Cook, L.M. Patrone, and R.G. Vanbuskirk, J. Toxicol. Cutan. Ocul. Toxicol. 12, 87 (1993).CrossRefGoogle Scholar
  51. 51.
    P.K. Shah, R.L. Bartel, and R.T. Borchardt, Int. J. Pharma. 68, 285 (1991).CrossRefGoogle Scholar
  52. 52.
    N.A. Monteiro-Riviere, A.O. Inman, T.H. Snider, J.A. Blank, and D.W. Hobson, Microsc. Res. Tech. 37, 172 (1997).CrossRefGoogle Scholar

Copyright information

© TMS 2012

Authors and Affiliations

  • Shelby A. Skoog
    • 1
  • Anirudha V. Sumant
    • 2
  • Nancy A. Monteiro-Riviere
    • 1
    • 3
  • Roger J. Narayan
    • 1
  1. 1.Joint Department of Biomedical EngineeringUniversity of North Carolina and North Carolina State UniversityRaleighUSA
  2. 2.Center for Nanoscale MaterialsArgonne National LaboratoryArgonneUSA
  3. 3.Center for Chemical Toxicology Research and Pharmacokinetics, Department of Clinical SciencesNorth Carolina State UniversityRaleighUSA

Personalised recommendations