Abstract
Functional activity of the bronchoalveolar lavage fluid (BALF) phagocytes was studied in 33 and 16 patients with fibro-cavernous and infiltrative pulmonary tuberculosis (FCPT and IPT, respectively). Complex examination of BALF, alveolar macrophages and neutrophils sedimented from BALF has shown interrelationship between functional activity of the cells and the form of pulmonary tuberculosis. Higher neopterin content and activity of elastase mainly secreted into BALF by activated alveolar macrophages and neutrophils, respectively, reflect higher secretory activity of both types of cells in FCPT. In FCPT this is combined with higher bactericidal activity of neutrophils, which significantly correlates with their adenosine deaminase (ADA) activity. Comparison of changes of the biochemical parameters studied in BALF (neopterin, elastase, ADA and its isoenzymes, 2-deoxy-ADA) and bactericidal activity of the sedimented cells obviously reflects different sides of BALF phagocytes functioning. Taking into consideration modern concepts on the mechanisms of regulation of phagocyte cells one may suggest the existence of differences in intercellular interactions in various forms of pulmonary tuberculosis.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Erokhin, V.V., in Tuberkulez. Problemy diagnostiki, lecheniya i profilaktiki. Trudy Vserossiiskoi nauchnoprakticheskoi konferentsii (Tuberculosis: Problems of Diagnistics, Treatment, and Prophylaxis, Proc. All-Russian Scientific Applied Conference), St. Petersburg, 2003, pp. 141–144.
Kaminskaya, G.O. and Abdullaev, R.Yu., Probl. Tub., 2002, no. 3, pp. 38–43.
Erokhin, V.V., Probl. Tub., 1998, no. 3, pp. 61–66.
Fuchs, D., Hausen, A., Reibnegger, G., Werner, E.R., Dierich, M.P., and Wachten, H., Immunol. Today, 1998, vol. 9, pp 150–155.
Murr, C., Fuith, L.C., Widner, B., Wirleitner, B., Baier-Bitterlich, G., and Fuchs, D., Anticancer Res., 1999, vol. 19, pp. 1721–1728.
Nasov, E.L., Rossiiskie Meditsinskie Vesti, 2001, vol. VI, no. 3, pp. 20–26.
Potapova, G.I., Khramtsova, S.N., Sukhova, T.I., and Mukhoyan, I.A., Vestnik RAMN, 1993, no. 4, pp. 3–7
Machinskii, A.I., Dotsenko, V.L., and Spirina, A.Ya., Probl. Tub., 2000, no. 4, pp. 36–39.
Filippov, VP., Diagnosticheskii bronkhoal’veolyarnyi lavazh (Diagnistic Bronchial Alveolar Lavage), Moscow, 1986.
Visser, L. and Blout, E.R., Biochim. Biophys. Acta, 1972, vol. 268, pp. 257–260.
Oglobina, O.G., Vop. Khim., 1980, no. 3, pp. 387–392.a
Giusti, G., in Methods of Enzymatic Analysis, Bergmeyer, H., Ed., New York, 1974, vol. 2, p. 1092.
Freidlin, I.S., Metody izucheniya fagotsitiruyushchikh kletok pri otsenke immunnogo statusa cheloveka (Methods for Studies of Phagocytic Cells during Evaluation of Immune Status in Man), St. Petersburg, 1984, p. 32.
Thomas, C.Y., Tsao, M.D., Ji-hong Hong, M.D., and Li-Fu, Li, Chest, 2000, vol. 117, pp. 103–109
Mohamed, K.H., Mobasher, A.A.M.T., Yousef, A.-R.I., and Salah, A., Chest, 2001, vol. 119, pp. 776–780.
Makinskii, A.I., Probl. Tub., 2004, n. 9, pp. 42–45.
Surkova, O.A., Pokhodzei, I.V., Aleksandrova, N.I., Bulychev, A.G., and Leonteva, E.A., Pul’monologiya, 1997, no. 4, pp. 55–59.
Pal’tsev, M.A., and Ivanov, A.A., Mezhkletochnye vzaimodeistviya (Intercellular Interactions), Moscow: Meditsina, 1995.
Author information
Authors and Affiliations
Corresponding author
Additional information
Original Russian Text © M.E. Dyakova, O.T. Titarenko, D.S. Esmedlyaeva, A.V. Yelkin, N.P. Alexeyeva, T.L. Perova, 2008, published in Biomeditsinskaya Khimiya.
Rights and permissions
About this article
Cite this article
Dyakova, M.E., Titarenko, O.T., Esmedlyaeva, D.S. et al. Functional activity of phagocytes of bronchoalveolar lavage in patients with fibro-cavernous and infiltrative pulmonary tuberculosis. Biochem. Moscow Suppl. Ser. B 2, 111–114 (2008). https://doi.org/10.1007/s11828-008-1014-z
Received:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s11828-008-1014-z