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Jammed microgels fabricated via various methods for biological studies

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Abstract

Microgels, hydrogels fabricated in microscale via various methods, can be jammed, and the jammed state can be influenced by some factors such as volume fraction (ϕ), pressure and temperature. Compared to bulk hydrogels, jammed microgels have distinct characteristics. Structures of jammed microgels, stable through a balance of effective forces applied to them, can be changed by application of forces or pressure, implying shear-thinnning properties. Additionally, the ability to maintain structures under a static condition and porous internal structures of them has been extensively exploited in researches. Additional materials can be involved in jammed microgels for additional features (e.g., conductivity), and overall mechanical properties can be also controlled. These characteristics have been used in diverse biological studies by developing them as injectable scaffolds, drug delivery vehicles and inks and support bath in 3D printing processes. In this review, jamming processes, characteristics of jammed microgels, fabrication methods of microgels and applications of jammed microgels are discussed to provide a comprehensive understanding of jammed microgels and promote their use in diverse researches.

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Acknowledgements

Kwang Hoon Song and Junsang Doh contributed equally to this work as corresponding authors. This research was financially supported by the Ministry of Trade, Industry and Energy (MOTIE) and Korea Institute for Advancement of Technology (KIAT) through the International Cooperative R&D program (p0011266), the National Research Council of Science & Technology (NST) grant by the Korea government (CAP-18-02-KRIBB), and the National Research Foundation of Korea (NRF) grant (No. NRF-2021R1 C1C1010633, No. NRF-2020R1A2B5B03001747).

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Authors and Affiliations

  1. Department of Mechanical Engineering, Pohang University of Science and Technology (POSTECH), Pohang, Gyeongbuk, 37673, Korea

    Dowon Moon

  2. Department of Nano-Bioengineering, Incheon National University, 119, Academy-ro, Yeonsu-gu, Incheon, 22012, Korea

    Kwang Hoon Song

  3. Department of Materials Science and Engineering, Seoul National University, Seoul, 08826, Korea

    Junsang Doh

  4. Research Institute of Advanced Materials (RIAM), Institute of Engineering Research, Seoul National University, Seoul, 08826, Korea

    Junsang Doh

  5. BioMAX Institute, Seoul National University, Seoul, 08826, Korea

    Junsang Doh

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  1. Dowon Moon
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Correspondence to Kwang Hoon Song or Junsang Doh.

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Moon, D., Song, K.H. & Doh, J. Jammed microgels fabricated via various methods for biological studies. Korean J. Chem. Eng. 40, 267–275 (2023). https://doi.org/10.1007/s11814-022-1310-1

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