Abstract
Neural diseases, like Alzheimer’s (AD) and Parkinson’s (PD) are widely expanding portions of neurodegenerative diseases, are related to norepinephrine (NE) concentration with proportional correlation. However, quantification of NE is quite difficult because NE coexists with ascorbic acid (AA) and uric acid (UA), which interferes with detecting NE in biological fluid. We fabricated a multi-modified electrode with reduced graphene oxide sheets (GS) and gold nanoparticles (GNPs) for highly selective and sensitive detection of NE. Thus, GS-GNPs modified electrode could enhance the sensitivity for detection of NE, as well as highly sensitive manner with AA. Compared with recent studies, our newly developed sensor appears to have not only a wide detection range (0.2-10 μM), but also superior detection limit (200 nM) in presence of 2000 times higher concentration of AA.
Similar content being viewed by others
References
D. Brambilla, B. Le Droumaguet, J. Nicolas, S. H. Hashemi, L.-P. Wu, S. M. Moghimi, P. Couvreur and K. Andrieux, Nanomed. Nanotech. Biol. Med., 7, 521 (2011).
Y.-H. Suh and F. Checler, Pharmacol. Rev., 54, 469 (2002).
D. Grieshaber, R. MacKenzie, J. Voeroes and E. Reimhult, Sensors, 8, 1400 (2008).
E. Szantai, A. Szilagyi, A. Guttman, M. Sasvari-Szekely and Z. Ronai, J. Chromatogr. A, 1053, 241 (2004).
K. E. Hubbard, A. Wells, T. S. Owens, M. Tagen, C. H. Fraga and C. F. Stewart, Biomed. Chromatogr., 24, 626 (2010).
F.-L. Chan, W.-Y. Chang, L.-M. Kuo, C.-H. Lin, S.-W. Wang, Y.-S. Yang and M. S. Lu, J. Micromech. Microeng., 18, 075028 (2008).
R. Shukla, V. Bansal, M. Chaudhary, A. Basu, R. R. Bhonde and M. Sastry, Langmuir, 21, 10644 (2005).
D. van Noort and C.-F. Mandenius, Biosens. Bioelectron., 15, 203 (2000).
C. Bansal, S. Sarkar, A. Mishra, T. Abraham, C. Lemier and H. Hahn, Sci. Mater., 56, 705 (2007).
K. Mao, D. Wu, Y. Li, H. Ma, Z. Ni, H. Yu, C. Luo, Q. Wei and B. Du, Anal. Biochem., 422, 22 (2012).
X. Li, G. Zhang, X. Bai, X. Sun, X. Wang, E. Wang and H. Dai, Nat. Nanotech., 3, 538 (2008).
C. Shan, H. Yang, D. Han, Q. Zhang, A. Ivaska and L. Niu, Biosens. Bioelectron., 25, 1504 (2010).
V. Singh, D. Joung, L. Zhai, S. Das, S. I. Khondaker and S. Seal, Prog. Mater. Sci., 56, 1178 (2011).
L. Chen, Y. Tang, K. Wang, C. Liu and S. Luo, Electrochem. Commun., 13, 133 (2011).
Y.-l. Yao, Y. Ding, L.-S. Ye and X.-H. Xia, Carbon, 44, 61 (2006).
J. O. Sass, D. Skladal and M. Brunner-Krainz, Metabolic Brain Disease, 14, 67 (1999).
D. Deletioglu, E. Hasdemir and A. O. Solak, Curr. Anal. Chem., 6, 203 (2010).
H. Yao, Y. Sun, X. Lin, Y. Tang and L. Huang, Anal. Chim., 97, 1217 (2007).
H. M. Moghaddam and H. Beitollahi, Int. J. Electrochem. Sci., 6, 6503 (2011).
X. Ma, M. Chen and X. Li, Int. J. Electrochem. Sci., 7, 991 (2012).
Author information
Authors and Affiliations
Corresponding author
Additional information
This article is dedicated to Prof. Ki-Pung Yoo on the occasion of his retirement from Sogang University.
The authors contributed equally in this work.
Rights and permissions
About this article
Cite this article
Lee, E.J., Choi, JH., Um, S.H. et al. Electrochemical sensor for selective detection of norepinephrine using graphene sheets-gold nanoparticle complex modified electrode. Korean J. Chem. Eng. 34, 1129–1132 (2017). https://doi.org/10.1007/s11814-016-0363-4
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s11814-016-0363-4